The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University Ramat-Gan, Israel.
Front Immunol. 2013 Mar 26;4:65. doi: 10.3389/fimmu.2013.00065. eCollection 2013.
The Natural Killer (NK) cell population is composed of subsets of varying sizes expressing different combinations of inhibitory receptors for MHC class I molecules. Genes within the NK gene complex, including the inhibitory receptors themselves, seem to be the primary intrinsic regulators of inhibitory receptor expression, but the MHC class I background is an additional Modulating factor. In this paper, we have performed a parallel study of the inhibitory receptor repertoire in inbred mice of the C57Bl/6 background and in a cohort of 44 humans. Deviations of subset frequencies from the "product rule (PR)," i.e., differences between observed and expected frequencies of NK cells, were used to identify MHC-independent and MHC-dependent control of receptor expression frequencies. Some deviations from the PR were similar in mice and humans, such as the decreased presence of NK cell subset lacking inhibitory receptors. Others were different, including a role for NKG2A in determining over- or under-representation of specific subsets in humans but not in mice. Thus, while human and murine inhibitory receptor repertoires differed in details, there may also be shared principles governing NK cell repertoire formation in these two species.
自然杀伤 (NK) 细胞群体由大小不同的亚群组成，这些亚群表达不同组合的 MHC Ⅰ类分子的抑制性受体。NK 基因复合物内的基因，包括抑制性受体本身，似乎是抑制性受体表达的主要内在调节因子，但 MHC Ⅰ类背景是另一个调节因素。在本文中，我们对 C57Bl/6 背景的近交系小鼠和 44 名人类的抑制性受体库进行了平行研究。通过观察到的 NK 细胞频率与预期频率之间的差异（即“乘积法则（PR）”偏差），用于识别 MHC 非依赖性和 MHC 依赖性受体表达频率的控制。一些与 PR 的偏差在小鼠和人类中是相似的，例如缺乏抑制性受体的 NK 细胞亚群的存在减少。其他则不同，包括 NKG2A 在决定人类特定亚群的过度或不足表达中的作用，但在小鼠中没有。因此，虽然人类和鼠类的抑制性受体库在细节上存在差异，但在这两个物种中，可能也存在共同的原则来控制 NK 细胞库的形成。
