Department of Diagnostic and Interventional Radiology, University Düsseldorf, Medical Faculty, Düsseldorf, Germany.
Muscle Nerve. 2013 Dec;48(6):889-96. doi: 10.1002/mus.23855. Epub 2013 Oct 4.
We investigated the utility of diffusion tensor imaging (DTI) for detecting neuropathic changes in proximal nerve segments in patients with peripheral neuropathy.
Twenty-one individuals with (n = 11) and without (n = 10) peripheral neuropathy underwent DTI of a defined sciatic nerve segment. Patients and controls were evaluated by clinical examination and nerve conduction studies at baseline and 6 months after the initial DTI scan.
The mean fractional anisotropy (FA) value was significantly lower in sciatic nerves from patients with peripheral neuropathy as compared with controls. Sciatic nerve FA values correlated with clinical disability scores and electrophysiological parameters of axonal damage at baseline and 6 months after MRI scan.
DTI-derived FA values are a sensitive measure to discriminate healthy from functionally impaired human sciatic nerve segments. DTI of proximal nerve segments may be useful for estimating the proximal axonal degeneration burden in patients with peripheral neuropathies.
我们研究了扩散张量成像（DTI）在检测周围神经病变患者近端神经节段神经病变中的效用。
21 名患有（n=11）和不患有（n=10）周围神经病的个体接受了特定坐骨神经节段的 DTI 检查。患者和对照组在基线时和首次 DTI 扫描后 6 个月接受临床检查和神经传导研究。
与对照组相比，患有周围神经病的患者的坐骨神经平均各向异性分数（FA）值明显降低。坐骨神经 FA 值与基线和 MRI 扫描后 6 个月的临床残疾评分和轴索性损伤的电生理参数相关。
DTI 衍生的 FA 值是区分健康和功能受损的人类坐骨神经节段的敏感指标。近端神经节段的 DTI 可能有助于估计周围神经病患者近端轴突变性负担。
