Wu Chao, Wang Guangbin, Zhao Yunxia, Hao Wen, Zhao Lianxin, Zhang Xinjuan, Cao Jinfeng, Wang Shanshan, Chen Weibo, Chan Queenie, Zhao Bin, Chhabra Avneesh
Department of MR, Shandong Medical Imaging Research Institute, Shandong University, 324, Jingwu Road, Jinan, Shandong, 250021, People's Republic of China.
Department of Electromyogram, Shandong provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China.
Eur Radiol. 2017 Aug;27(8):3523-3531. doi: 10.1007/s00330-016-4698-3. Epub 2016 Dec 21.
To determine the diagnostic accuracy and interobserver performance of diffusion tensor imaging (DTI) in diabetic peripheral neuropathy (DPN) and detect correlations with electrophysiology.
Twelve healthy volunteers (controls) and ten DPN patients were enrolled to undergo MR examinations. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values of tibial nerve (TN) and common peroneal nerve (CPN) were measured. Unpaired t test and Levene tests were performed to assess differences between the two groups. Receiver operating characteristic (ROC) analysis was performed for FA and ADC values. Pearson correlation coefficient was used to assess the correlation between DTI and electrophysiology parameters in the patient group.
The FA values of TN and CPN in the DPN group were significantly lower and ADC were higher than the control group (p < 0.05). Interobserver agreement was excellent. FA positively correlated and ADC negatively correlated with motor nerve conduction velocity (MCV) (p < 0.05). There were no significant differences between motor nerve conduction amplitude and DTI parameters (p > 0.05). Moderate diagnostic accuracy of DTI was seen in the diagnosis of DPN.
DTI demonstrates moderate diagnostic accuracy and excellent interobserver performance in the detection of DPN involving the TN and CPN. There is moderate correlation with MCV.
• FA values of TN and CPN are significantly lower in DPN. • ADC values of TN and CPN are significantly higher in DPN. • DTI demonstrates moderate diagnostic accuracy in detection of DPN. • There is excellent interobserver performance in DTI measurements. • Moderate correlation is seen between DTI parameters and MCV.
确定弥散张量成像（DTI）在糖尿病周围神经病变（DPN）中的诊断准确性及观察者间的一致性，并检测其与电生理学的相关性。
纳入12名健康志愿者（对照组）和10名DPN患者进行磁共振检查。测量胫神经（TN）和腓总神经（CPN）的分数各向异性（FA）值和表观扩散系数（ADC）值。采用独立样本t检验和Levene检验评估两组间差异。对FA值和ADC值进行受试者操作特征（ROC）分析。采用Pearson相关系数评估患者组中DTI与电生理学参数之间的相关性。
DPN组中TN和CPN的FA值显著低于对照组，ADC值高于对照组（p < 0.05）。观察者间一致性良好。FA与运动神经传导速度（MCV）呈正相关，ADC与MCV呈负相关（p < 0.05）。运动神经传导幅度与DTI参数之间无显著差异（p > 0.05）。DTI在DPN诊断中显示出中等诊断准确性。
DTI在检测累及TN和CPN的DPN中显示出中等诊断准确性和良好的观察者间一致性。与MCV存在中等相关性。
• DPN中TN和CPN的FA值显著降低。• DPN中TN和CPN的ADC值显著升高。• DTI在DPN检测中显示出中等诊断准确性。• DTI测量具有良好的观察者间一致性。• DTI参数与MCV之间存在中等相关性。
