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蒙特卡罗N粒子代码 - 非均匀体模中临床电子束的剂量分布

Monte Carlo N Particle code - Dose distribution of clinical electron beams in inhomogeneous phantoms.

作者信息

Nedaie H A, Mosleh-Shirazi M A, Allahverdi M

机构信息

Department of Radiotherapy Physics, Cancer Research Centre, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Med Phys. 2013 Jan;38(1):15-21. doi: 10.4103/0971-6203.106607.

Abstract

Electron dose distributions calculated using the currently available analytical methods can be associated with large uncertainties. The Monte Carlo method is the most accurate method for dose calculation in electron beams. Most of the clinical electron beam simulation studies have been performed using non- MCNP [Monte Carlo N Particle] codes. Given the differences between Monte Carlo codes, this work aims to evaluate the accuracy of MCNP4C-simulated electron dose distributions in a homogenous phantom and around inhomogeneities. Different types of phantoms ranging in complexity were used; namely, a homogeneous water phantom and phantoms made of polymethyl methacrylate slabs containing different-sized, low- and high-density inserts of heterogeneous materials. Electron beams with 8 and 15 MeV nominal energy generated by an Elekta Synergy linear accelerator were investigated. Measurements were performed for a 10 cm × 10 cm applicator at a source-to-surface distance of 100 cm. Individual parts of the beam-defining system were introduced into the simulation one at a time in order to show their effect on depth doses. In contrast to the first scattering foil, the secondary scattering foil, X and Y jaws and applicator provide up to 5% of the dose. A 2%/2 mm agreement between MCNP and measurements was found in the homogenous phantom, and in the presence of heterogeneities in the range of 1-3%, being generally within 2% of the measurements for both energies in a "complex" phantom. A full-component simulation is necessary in order to obtain a realistic model of the beam. The MCNP4C results agree well with the measured electron dose distributions.

摘要

使用当前可用的分析方法计算出的电子剂量分布可能存在很大的不确定性。蒙特卡罗方法是电子束剂量计算中最准确的方法。大多数临床电子束模拟研究都是使用非MCNP[蒙特卡罗N粒子]代码进行的。鉴于蒙特卡罗代码之间的差异,这项工作旨在评估MCNP4C在均匀体模和不均匀性周围模拟的电子剂量分布的准确性。使用了不同类型、复杂度各异的体模;即一个均匀的水体模以及由聚甲基丙烯酸甲酯平板制成的体模,其中包含不同尺寸、低密度和高密度的异质材料插入物。研究了由医科达Synergy直线加速器产生的标称能量为8和15 MeV的电子束。在源皮距为100 cm的情况下,对一个10 cm×10 cm的限束器进行了测量。一次将束流限定系统的各个部分引入模拟,以显示它们对深度剂量的影响。与第一散射箔不同,第二散射箔、X和Y光阑以及限束器提供的剂量高达5%。在均匀体模中,发现MCNP与测量结果之间的一致性为2%/2 mm,在存在不均匀性的情况下,一致性在1 - 3%范围内,在“复杂”体模中,两种能量下的测量结果通常都在测量值的2%以内。为了获得束流的真实模型,需要进行全组件模拟。MCNP4C的结果与测量得到的电子剂量分布吻合良好。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8e3e/3607340/8ff0bdef09bf/JMP-38-15-g001.jpg

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