Unitat de Recerca Biomèdica, Hospital Universitari Sant Joan, Institut d'Investigació Sanitària Pere Virgili, Universitat Rovira i Virgili, carrer Sant Llorenç 21, 43201 Reus, Spain.
Mediators Inflamm. 2013;2013:135698. doi: 10.1155/2013/135698. Epub 2013 Feb 28.
Obesity is not necessarily a predisposing factor for disease. It is the handling of fat and/or excessive energy intake that encompasses the linkage of inflammation, oxidation, and metabolism to the deleterious effects associated with the continuous excess of food ingestion. The roles of cytokines and insulin resistance in excessive energy intake have been studied extensively. Tobacco use and obesity accompanied by an unhealthy diet and physical inactivity are the main factors that underlie noncommunicable diseases. The implication is that the management of energy or food intake, which is the main role of mitochondria, is involved in the most common diseases. In this study, we highlight the importance of mitochondrial dysfunction in the mutual relationships between causative conditions. Mitochondria are highly dynamic organelles that fuse and divide in response to environmental stimuli, developmental status, and energy requirements. These organelles act to supply the cell with ATP and to synthesise key molecules in the processes of inflammation, oxidation, and metabolism. Therefore, energy sensors and management effectors are determinants in the course and development of diseases. Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.
肥胖不一定是疾病的诱发因素。正是脂肪和/或过多能量摄入的处理，将炎症、氧化和代谢与持续过量摄入食物相关的有害影响联系起来。细胞因子和胰岛素抵抗在过多能量摄入中的作用已经得到了广泛的研究。烟草使用以及肥胖、不健康的饮食和缺乏身体活动是导致非传染性疾病的主要因素。这意味着，能量或食物摄入的管理，这是线粒体的主要作用，与最常见的疾病有关。在这项研究中，我们强调了线粒体功能障碍在因果关系之间相互关系中的重要性。线粒体是高度动态的细胞器，它们会根据环境刺激、发育状态和能量需求而融合和分裂。这些细胞器为细胞提供 ATP，并在炎症、氧化和代谢过程中合成关键分子。因此，能量传感器和管理效应物是疾病过程和发展的决定因素。调节线粒体功能可能需要一种多方面的方法，包括具有抗氧化和抗炎活性的药物和植物源性酚类化合物，这些化合物可以改善线粒体生物发生，并调节 AMPK/mTOR 途径。
