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Anticoagulant effect of inositol hexasulfate as measurable by clotting times of fibrinogen and recalcified plasma.

作者信息

Oshima G

机构信息

School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.

出版信息

Thromb Res. 1990 May 1;58(3):243-50. doi: 10.1016/0049-3848(90)90094-s.

DOI:10.1016/0049-3848(90)90094-s
PMID:2353338
Abstract

Thrombin-clotting time of fibrinogen was delayed by inositol hexasulfate (IHS). Clotting time of the recalcified plasma was also delayed by IHS. Moreover, when IHS was intravenously injected into anesthetized male rabbits (0.11 mmoles/kg), it delayed clotting time of the recalcified plasma. IHS prevented generations of factor Xa and thrombin in the recalcified plasma. It is probable that IHS inhibits the clot-formation of the recalcified plasma in competition with calcium ions.

摘要

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