Department of Internal Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea College of Medicine, Uijeongbu 480717, Republic of Korea.
Gastroenterol Res Pract. 2013;2013:201810. doi: 10.1155/2013/201810. Epub 2013 Feb 28.
Background/Aim. Hepcidin, an iron regulatory hormone, is increased in response to inflammation and some infections. We investigated the relationships among serum prohepcidin, iron status, Helicobacter pylori infection status, and the presence of gastric mucosal atrophy. Methods. Seventy subjects undergoing esophagogastroduodenoscopy underwent multiple gastric biopsies, and the possibility of H. pylori infection and the degree of endoscopic and histologic gastritis were investigated. In all subjects, serum prohepcidin and iron parameters were evaluated. Results. No correlations were observed between serum prohepcidin levels and the other markers of anemia, such as hemoglobin, serum iron, ferritin, and total iron binding capacity. Serum prohepcidin levels were not significantly different between the H. pylori-positive group and the H. pylori-negative group. Serum prohepcidin levels in atrophic gastritis patients were significantly lower than those in subjects without atrophic gastritis irrespective of H. pylori infection. Conclusion. Serum prohepcidin levels were not altered by H. pylori infection. Serum prohepcidin levels decrease in patients with atrophic gastritis, irrespective of H. pylori infection. It suggests that hepcidin may decrease due to gastric atrophy, a condition that causes a loss of hepcidin-producing parietal cells. Further investigations with a larger number of patients are necessary to substantiate this point.
背景/目的：铁调素是一种铁调节激素，会因炎症和某些感染而增加。我们研究了血清前铁调素、铁状态、幽门螺杆菌感染状态与胃黏膜萎缩之间的关系。
70 例行食管胃十二指肠镜检查的患者接受了多次胃活检，并对幽门螺杆菌感染的可能性以及内镜和组织学胃炎的程度进行了调查。在所有患者中，评估了血清前铁调素和铁参数。
血清前铁调素水平与贫血的其他标志物（如血红蛋白、血清铁、铁蛋白和总铁结合能力）之间无相关性。幽门螺杆菌阳性组和幽门螺杆菌阴性组之间血清前铁调素水平无显著差异。萎缩性胃炎患者的血清前铁调素水平明显低于无萎缩性胃炎的患者，而与幽门螺杆菌感染无关。
血清前铁调素水平不受幽门螺杆菌感染的影响。在有或没有幽门螺杆菌感染的情况下，患有萎缩性胃炎的患者血清前铁调素水平降低。这表明，由于胃萎缩导致产生铁调素的壁细胞丢失，铁调素可能会减少。需要更多的患者进行进一步的研究来证实这一点。
