Department of Nephrology, The Second Hospital of Jilin University, 218 Ziqiang Street, Changchun, Jilin Province 130041, China.
Oxid Med Cell Longev. 2013;2013:306073. doi: 10.1155/2013/306073. Epub 2013 Mar 7.
So far, cardiovascular and renal diseases have brought us not only huge economic burden but also serious society problems. Since effective therapeutic strategies are still limited, to find new methods for the prevention or therapy of these diseases is important. Oxidative stress has been found to play a critical role in the initiation and progression of cardiovascular and renal diseases. In addition, activation of nuclear-factor-E2-related-factor-2- (Nrf2-) antioxidant-responsive element (ARE) signaling pathway protects cells and tissues from oxidative damage. As a proteasomal inhibitor, MG132 was reported to activate Nrf2 expression and function, which was accompanied with significant preventive and/or therapeutic effect on cardiovascular and renal diseases under most conditions; therefore, MG132 seems to be a potentially effective drug to be used in the prevention of oxidative damage. In this paper, we will summarize the information available regarding the effect of MG132 on oxidative stress-induced cardiovascular and renal damage, especially through Nrf2-ARE signaling pathway.
到目前为止，心血管疾病和肾脏疾病不仅给我们带来了巨大的经济负担，也给社会带来了严重的问题。由于有效的治疗策略仍然有限，因此寻找预防或治疗这些疾病的新方法很重要。氧化应激被发现在心血管疾病和肾脏疾病的发生和发展中起着关键作用。此外，核因子-E2 相关因子-2-（Nrf2）抗氧化反应元件（ARE）信号通路的激活可以保护细胞和组织免受氧化损伤。作为一种蛋白酶体抑制剂，MG132 被报道可以激活 Nrf2 的表达和功能，在大多数情况下，它对心血管疾病和肾脏疾病具有显著的预防和/或治疗作用；因此，MG132 似乎是一种潜在有效的药物，可用于预防氧化损伤。本文将总结关于 MG132 对氧化应激诱导的心血管和肾脏损伤的作用的现有信息，特别是通过 Nrf2-ARE 信号通路。
