Wakabayashi Taku, Ikuno Yasushi, Oshima Yusuke, Hamasaki Toshimitsu, Nishida Kohji
Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
J Ophthalmol. 2013;2013:257381. doi: 10.1155/2013/257381. Epub 2013 Mar 6.
Purpose. To investigate aqueous concentrations of vascular endothelial growth factor (VEGF) in eyes with myopic choroidal neovascularization (CNV). Methods. Aqueous samples were collected, and VEGF concentrations were measured by enzyme-linked immunosorbent assay in 16 eyes (16 patients) with active myopic CNV, 23 eyes (16 patients) with high myopia without myopic CNV, and 8 control eyes (7 patients). Differences in the concentrations of VEGF in each group were compared. Results. The estimated mean VEGF concentrations were significantly lower in eyes with myopic CNV (82.0 pg/mL) (P = 0.016 ) and with high myopia without myopic CNV (58.9 pg/mL) (P < 0.001) compared with controls (116.6 pg/mL). The estimated mean VEGF concentration was significantly (P < 0.05) higher in eyes with myopic CNV than in those without myopic CNV in highly myopic eyes. In eyes with high myopia with and without CNV, the VEGF concentration was significantly (stepwise regression analysis, R = 0.325, P = 0.044) associated with the presence of myopic CNV but not with age, axial length, or intraocular pressure. Conclusion. Increased levels of VEGF may play a role in the pathogenesis of CNV in highly myopic eyes.
目的。研究近视性脉络膜新生血管（CNV）患者眼房水中血管内皮生长因子（VEGF）的浓度。方法。收集房水样本，采用酶联免疫吸附测定法测量16只眼（16例患者）活动性近视性CNV、23只眼（16例患者）高度近视但无近视性CNV以及8只对照眼（7例患者）的VEGF浓度。比较各组VEGF浓度的差异。结果。与对照组（116.6 pg/mL）相比，近视性CNV患者眼（82.0 pg/mL）（P = 0.016）以及高度近视但无近视性CNV患者眼（58.9 pg/mL）（P < 0.001）的VEGF估计平均浓度显著降低。在高度近视眼中，近视性CNV患者眼的VEGF估计平均浓度显著高于（P < 0.05）无近视性CNV的患者眼。在有和无CNV的高度近视眼中，VEGF浓度与近视性CNV的存在显著相关（逐步回归分析，R = 0.325，P = 0.044），但与年龄、眼轴长度或眼压无关。结论。VEGF水平升高可能在高度近视眼中CNV的发病机制中起作用。
