Christian Jennifer B, Olson Eric J, Allen Jeffery K, Lowe Kimberly A
GlaxoSmithKline, Clinical Effectiveness & Safety, 5 Moore Drive, B.3116, Durham, NC 27709-3398, USA.
Cholesterol. 2013;2013:681475. doi: 10.1155/2013/681475. Epub 2013 Feb 26.
Background. Niacin is the most effective treatment currently available for raising HDL-C levels. Objective. To evaluate if gender and baseline lipid levels have an effect on the HDL-C response of niacin ER and to identify factors that predict response to niacin ER at the 500 mg dose. Material and Methods. The change in HDL-C effect between baseline and follow-up levels was quantified in absolute change as well as dichotomized into high versus low response (high response was defined as an HDL-C effect of >15% increase and low response was HDL-C <5%) in a sample of 834 individuals. Results. Both males and females with low HDL-C levels at baseline exhibited a response to treatment in the multivariate model (males, HDL-C <40 mg/dL: OR = 5.18, 95% CI: 2.36-11.39; females, HDL-C <50 mg/dL: OR = 5.40, 95% CI: 1.84-15.79). There was also a significant difference in the mean HDL-C effect between baseline and follow-up HDL-C levels in the 500 mg niacin ER dose group for both males (mean HDL-C effect = 0.08, P < 0.001) and females (mean HDL-C effect = 0.10, P = 0.019). Conclusion. Baseline HDL-C levels are the biggest predictor of response to niacin ER treatment for both males and females among the factors evaluated.
背景。烟酸是目前可用于提高高密度脂蛋白胆固醇（HDL-C）水平的最有效治疗方法。目的。评估性别和基线血脂水平是否对缓释烟酸的HDL-C反应有影响，并确定预测500毫克剂量缓释烟酸反应的因素。材料与方法。在834名个体的样本中，将基线水平与随访水平之间HDL-C效应的变化以绝对变化量进行量化，并分为高反应与低反应（高反应定义为HDL-C效应增加>15%，低反应为HDL-C<5%）。结果。在多变量模型中，基线时HDL-C水平低的男性和女性均对治疗有反应（男性，HDL-C<40毫克/分升：比值比[OR]=5.18，95%置信区间[CI]：2.36 - 11.39；女性，HDL-C<50毫克/分升：OR = 5.40，95%CI：1.84 - 15.79）。在500毫克缓释烟酸剂量组中，男性（平均HDL-C效应 = 0.08，P<0.001）和女性（平均HDL-C效应 = 0.10，P = 0.019）的基线HDL-C水平与随访HDL-C水平之间的平均HDL-C效应也存在显著差异。结论。在所评估的因素中，基线HDL-C水平是男性和女性对缓释烟酸治疗反应的最大预测因素。
