Kudo Shin-Ei, Sugihara Yuusaku, Kida Hiroyuki, Ishida Fumio, Miyachi Hideyuki, Mori Yuichi, Misawa Masashi, Hisayuki Tomokazu, Kodama Kenta, Wakamura Kunihiko, Hayashi Takemasa, Wada Yoshiki, Hamatani Shigeharu
Digestive Disease Center Showa University Northern Yokohama Hospital, Chigasaki Chuo 35-1, Tsuzuki-ku, Yokohama, Kanagawa-ken 224-8503, Japan.
ISRN Gastroenterol. 2013;2013:838134. doi: 10.1155/2013/838134. Epub 2013 Feb 27.
Familial adenomatous polyposis (FAP) is the most common inherited polyposis syndrome. Almost all patients with FAP will develop colorectal cancer if their FAP is not identified and treated at an early stage. Although there are many reports about polypoid lesions and colorectal cancers in FAP patients, little information is available concerning depressed lesions in FAP patients. Several reports suggested that depressed-type lesions are characteristic of FAP and important in the light of their rapid growth and high malignancy. Here, we describe the occurrence of depressed-type lesions in FAP patients treated at our institution. Between April 2001 and March 2010, eight of 18 FAP patients had colorectal cancers. Depressed-type colorectal cancer was found in three patients. It should be kept in mind that depressed-type lesions occur even in FAP.
家族性腺瘤性息肉病（FAP）是最常见的遗传性息肉病综合征。几乎所有FAP患者若在早期未得到诊断和治疗，都会发展为结直肠癌。尽管有许多关于FAP患者息肉样病变和结直肠癌的报道，但关于FAP患者凹陷性病变的信息却很少。有几份报告表明，凹陷型病变是FAP的特征，鉴于其生长迅速和高恶性程度，这些病变很重要。在此，我们描述了在我们机构接受治疗的FAP患者中凹陷型病变的发生情况。在2001年4月至2010年3月期间，18例FAP患者中有8例患有结直肠癌。3例患者发现有凹陷型结直肠癌。应记住，即使在FAP患者中也会出现凹陷型病变。
