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Malignant müllerian mixed tumor of the uterine cervix with a small cell neuroendocrine carcinoma component.

作者信息

Munakata Satoru, Iwai Emi, Tanaka Tomohito, Nakamura Michihiko, Kanda Takayoshi

机构信息

Department of Pathology, Osaka Minami Medical Center, 2-1 Kidohigashi, Kawachinagano, Osaka 586-8521, Japan ; Department of Pathology, Sakai City Hospital, 2-7, Daigakucho, Takatsuki, Osaka 569-8686, Japan.

出版信息

Case Rep Pathol. 2013;2013:630859. doi: 10.1155/2013/630859. Epub 2013 Feb 26.

DOI:10.1155/2013/630859
PMID:23533892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3600347/
Abstract

Malignant Müllerian mixed tumors (MMMTs) of the uterine cervix are extremely rare, accounting for 0.005% of all cervical malignancies. To date, only approximately 50 well-documented cases have been reported. Although several epithelial components have been described in cervical MMMTs, small cell neuroendocrine carcinoma (SCC) has not appeared in the English literature. We present a 43-year-old woman, para 2 gravida 2, who had MMMT with SCC and rhabdomyosarcoma components in the uterine cervix. She was referred to our hospital because of a cervical mass with an abnormal Pap smear result. Cervical biopsy revealed SCC. After neoadjuvant chemotherapy with balloon-occluded arterial infusion, she underwent type II radical hysterectomy with pelvic lymphadenectomy. Histological analysis revealed that the cervical tumor comprised SCC and rhabdomyosarcoma components. Genotype analysis indicated human papillomavirus type 18. She underwent concurrent chemoradiation therapy. The patient had been free of the disease and showed no evidence of recurrence 38 months after operation.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/75ef5805d1a7/CRIM.PATHOLOGY2013-630859.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/fc11682bc2f2/CRIM.PATHOLOGY2013-630859.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/8f84ec018a0b/CRIM.PATHOLOGY2013-630859.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/75ef5805d1a7/CRIM.PATHOLOGY2013-630859.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/fc11682bc2f2/CRIM.PATHOLOGY2013-630859.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/8f84ec018a0b/CRIM.PATHOLOGY2013-630859.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80c9/3600347/75ef5805d1a7/CRIM.PATHOLOGY2013-630859.003.jpg

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本文引用的文献

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Malignant mixed mullerian tumor of the cervix including components of a rhabdomyosarcoma: case report and literature review.
Eur J Gynaecol Oncol. 2010;31(4):462-6.
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Small cell carcinoma of the cervix: treatment and survival outcomes of 188 patients.宫颈小细胞癌：188 例患者的治疗和生存结局。
Am J Obstet Gynecol. 2010 Oct;203(4):347.e1-6. doi: 10.1016/j.ajog.2010.04.019. Epub 2010 Jul 1.
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Small cell carcinoma with skeletal muscle differentiation of urinary bladder.膀胱具有骨骼肌分化的小细胞癌
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Small cell neuroendocrine carcinomas of the uterine cervix: a histological, immunohistochemical, and molecular genetic study.子宫颈小细胞神经内分泌癌：一项组织学、免疫组织化学及分子遗传学研究
Int J Gynecol Pathol. 2004 Oct;23(4):366-72. doi: 10.1097/01.pgp.0000139637.01977.61.
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Merkel cell (primary neuroendocrine) carcinoma of the skin with nodal metastasis showing rhabdomyosarcomatous differentiation.
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Int J Gynecol Cancer. 2002 Mar-Apr;12(2):223-7. doi: 10.1046/j.1525-1438.2002.01100.x.
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Carcinosarcoma of the uterine cervix: a report of eight cases with immunohistochemical analysis and evaluation of human papillomavirus status.子宫颈癌肉瘤：8例报告及免疫组织化学分析与人乳头瘤病毒状态评估
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