伴有神经内分泌分化的子宫颈恶性苗勒管混合瘤
Malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.
作者信息
Ribeiro-Silva Alfredo, Novello-Vilar A, Cunha-Mercante A M, De Angelo Andrade L A L
机构信息
Department of Pathology, Faculty of Medicine of Ribeirão Preto, University of São Paulo (FMRP/USP), Avenida Bandeirantes, s/n-Campus Universitário Monte Alegre, CEP 14048-900, Ribeirão Preto-SP, São Paulo, Brazil.
出版信息
Int J Gynecol Cancer. 2002 Mar-Apr;12(2):223-7. doi: 10.1046/j.1525-1438.2002.01100.x.
Malignant mixed Mullerian tumors (MMMTs) are rare neoplasms. We report the clinical, pathologic, and immunohistochemical features of an MMMT primary of uterine cervix. This lesion was composed of a poorly differentiated epithelial component (cytokeratin positive) and a spindle cell component (vimentin positive) with heterologous (myoblastic) differentiation (focal 1A4 positive). There were also cells with neuroendocrine features that expressed S-100 and chromogranin A. Along with a brief review of this amazing neoplasm, some histogenetic concepts relevant to this case are discussed. To our knowledge this is the first report of a malignant mixed Mullerian tumor of the uterine cervix with neuroendocrine differentiation.
恶性苗勒管混合瘤（MMMTs）是罕见的肿瘤。我们报告一例原发性宫颈MMMT的临床、病理及免疫组化特征。该病变由低分化上皮成分（细胞角蛋白阳性）和梭形细胞成分（波形蛋白阳性）组成，伴有异源性（成肌细胞性）分化（局灶性1A4阳性）。还有具有神经内分泌特征的细胞，表达S-100和嗜铬粒蛋白A。在简要回顾这一罕见肿瘤的同时，讨论了与该病例相关的一些组织发生学概念。据我们所知，这是首例具有神经内分泌分化的宫颈恶性苗勒管混合瘤的报告。
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