Eke Koyuncu Ceren, Turkmen Yildirmak Sembol, Temizel Mustafa, Ozpacaci Tevfik, Gunel Pinar, Cakmak Mustafa, Ozbanazi Yüksel Gülen
Department of Clinical Biochemistry, Ministry of Health Okmeydani Educational and Research Hospital, Okmeydani, Istanbul 34384, Turkey.
J Thyroid Res. 2013;2013:306750. doi: 10.1155/2013/306750. Epub 2013 Feb 24.
Introduction. The aim of this study was to evaluate the serum levels of resistin and insulin-like growth factor-1 (IGF-1) and and also the potential relationship between thyroid function and levels of resistin and IGF-1 in hypothyroid and hyperthyroid patients. Methods. Fifteen cases of hypothyroid (HT), 16 of subclinically hypothyroid (SCHT), 15 of hyperthyroid (HrT), 15 of subclinically hyperthyroid (SCHrT), and 17 healthy individuals have been included in the study. Serum resistin levels were measured using enzyme-linked immunosorbent assay and IGF-1 and thyroid stimulating hormone (TSH) levels by chemiluminescence method. Results. Resistin levels in total HT group were significantly higher than in controls (12.66 ± 6.04 and 8.45 ± 2.90 ng/mL, resp.). In SCHrT subgroup resistin levels were significantly higher than those of controls (14.88 ± 7.73 and 8.45 ± 2.90 ng/mL, resp.). IGF-1 levels were significantly lower in total HT than in total HrT and control groups (117.22 ± 52.03, 155.17 ± 51.67, and 184.00 ± 49.73 ng/mL, resp.). Furthermore IGF-1 levels in HT subgroup were significantly lower compared to controls (123.70 ± 44.03 and 184 ± 49.73 ng/mL, resp.). In SCHT subgroup IGF-1 levels were significantly lower than those of control and SCHrT groups (111.11 ± 59.35, 184.00 ± 49.73, and 166.60 ± 47.87 ng/mL, resp.). There were significant correlations between IGF-1 and TSH in HT subgroup and between resistin and TSH in total HrT group. Conclusion. It was concluded that increased resistin levels are directly related to thyroid dysfunction, and GH/IGF-1 axis is influenced in clinically or subclinically hypothyroidism patients.
引言。本研究的目的是评估甲状腺功能减退和甲状腺功能亢进患者血清抵抗素和胰岛素样生长因子-1（IGF-1）水平，以及甲状腺功能与抵抗素和IGF-1水平之间的潜在关系。方法。本研究纳入了15例甲状腺功能减退（HT）患者、16例亚临床甲状腺功能减退（SCHT）患者、15例甲状腺功能亢进（HrT）患者、15例亚临床甲状腺功能亢进（SCHrT）患者以及17名健康个体。采用酶联免疫吸附测定法测量血清抵抗素水平，采用化学发光法测量IGF-1和促甲状腺激素（TSH）水平。结果。HT组总体抵抗素水平显著高于对照组（分别为12.66±6.04和8.45±2.90 ng/mL）。在SCHrT亚组中，抵抗素水平显著高于对照组（分别为14.88±7.73和8.45±2.90 ng/mL）。HT组总体IGF-1水平显著低于HrT组和对照组（分别为117.22±52.03、155.17±51.67和184.00±49.73 ng/mL）。此外，HT亚组的IGF-1水平显著低于对照组（分别为123.70±44.03和184±49.73 ng/mL）。在SCHT亚组中，IGF-1水平显著低于对照组和SCHrT组（分别为111.11±59.35、184.00±49.73和166.60±47.87 ng/mL）。HT亚组中IGF-1与TSH之间以及HrT组总体中抵抗素与TSH之间存在显著相关性。结论。得出结论：抵抗素水平升高与甲状腺功能障碍直接相关，并且生长激素/IGF-1轴在临床或亚临床甲状腺功能减退患者中受到影响。
