Department of Thoracic Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Department of Pathophysiology and Endocrinology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 41-800 Zabrze, Poland.
Int J Environ Res Public Health. 2021 Sep 7;18(18):9434. doi: 10.3390/ijerph18189434.
Development of obesity is primarily the result of imbalance between energy intake and energy expenditure. Thyroid hormones influence energy expenditure by regulating cellular respiration and thermogenesis and by determining resting metabolic rate. Triiodothyronine influences lipid turnover in adipocytes and impacts appetite regulation through the central nervous system, mainly the hypothalamus. Thyroid-stimulating hormone may also influence thermogenesis, suppress appetite and regulate lipid storage through lipolysis and lipogenesis control. Subclinical hypothyroidism may induce changes in basal metabolic rate with subsequent increase in BMI, but obesity can also affect thyroid function via several mechanisms such as lipotoxicity and changes in adipokines and inflammatory cytokine secretion. The present study investigated the complex and mutual relationships between the thyroid axis and adiposity.
肥胖的发展主要是由于能量摄入和能量消耗之间的失衡造成的。甲状腺激素通过调节细胞呼吸和产热以及决定静息代谢率来影响能量消耗。三碘甲状腺原氨酸影响脂肪细胞中的脂质周转，并通过中枢神经系统（主要是下丘脑）影响食欲调节。促甲状腺激素也可能通过控制脂肪分解和脂肪生成来影响产热、抑制食欲和调节脂质储存。亚临床甲状腺功能减退症可能会导致基础代谢率发生变化，随后 BMI 增加，但肥胖也可以通过脂毒性和脂肪因子和炎症细胞因子分泌的变化等多种机制影响甲状腺功能。本研究探讨了甲状腺轴与肥胖之间的复杂和相互关系。
