Institute of Physiology, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, 630117, Russia.
Biomed Environ Sci. 2013 Apr;26(4):284-94. doi: 10.3967/0895-3988.2013.04.007.
To verify whether peripheral blood circulation and arterial wall distensibility are influenced by atmospheric pressure (AtPr) and to examine if their association is dependent on age and/or sex.
Associations among natural AtPr levels (on the examination day as well as 1 and 2 days prior), limb muscle hemodynamics, and distensibility of conduit arteries were retrospectively examined in an observational study of 276 untreated patients with primary moderate hypertension (mean age 56.4 years, 194 men). Forearm and calf circulations at rest and 3 min after ischemia were measured by venous occlusion plethysmography. Compliance of the brachial and shank arteries was assessed by oscillometry.
After adjustment for age, degree of hypertension, and season, correlation and multiple regression analyses revealed a season-independent but age-dependent direct correlation between the stiffness of limb arteries and AtPr levels on the examination day in men, but not women. The association weakened with the degree of hypertension, disappeared with age, and was more evident in the arms than in the legs.
Parameters of arterial wall distensibility in adult hypertensive men are susceptible to AtPr changes within the usually observed limits (730-770 mmHg). It is proposed that reduction of arterial wall barometric responsiveness in women and aging men is a likely mechanism underlying their meteosensitivity.
验证外周血液循环和动脉壁顺应性是否受大气压（AtPr）的影响，并研究其相关性是否取决于年龄和/或性别。
在一项对 276 例未经治疗的原发性中度高血压患者（平均年龄 56.4 岁，194 名男性）的观察性研究中，回顾性分析了自然大气压水平（在检查日以及前 1 天和 2 天）、肢体肌肉血液动力学和导管动脉顺应性之间的关联。通过静脉阻塞体积描记法测量休息时和缺血后 3 分钟时的前臂和小腿循环。通过振荡测量法评估肱动脉和胫动脉的顺应性。
在调整年龄、高血压程度和季节后，相关和多元回归分析显示，在男性中，肢体动脉僵硬与检查日当天的大气压水平之间存在与季节无关但与年龄相关的直接相关性，但在女性中则没有。这种关联随着高血压程度的增加而减弱，随着年龄的增加而消失，在手臂中比在腿部中更为明显。
成年高血压男性的动脉壁顺应性参数易受通常观察到的大气压变化（730-770mmHg）的影响。据推测，女性和老年男性动脉壁对气压变化的反应性降低是其天气敏感性的可能机制。
