Liu Yun-yu, Zhang Xin, Shi Dong, Cheng Zhi-bin, Meng Huan-xin
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Jan;48(1):3-6.
To detect the plasma leptin levels in patients with aggressive periodontitis (AgP) and to analyze the relationship between circulating leptin level and periodontal condition.
A total of 97 patients with AgP and 44 healthy controls were recruited. Detailed clinical examinations were conducted and clinical parameters such as bleeding index (BI), probing depth (PD), attachment loss (AL) were recorded. Plasma leptin level was measured by enzyme-linked immunosorbent assay.
The plasma leptin level in AgP group was significantly higher than that of control subjects [(20.0 ± 4.3) µg/L vs. (7.5 ± 1.3) µg/L, P < 0.01)]. The plasma leptin level was positively related to BI, PD and AL, and the r values were 0.647, 0.596 and 0.632 respectively (P < 0.01).
Plasma leptin concentration in AgP patients was significantly elevated compared with healthy controls. Circulating leptin level was positively related to periodontal parameters including BI, PD and AL.
检测侵袭性牙周炎（AgP）患者的血浆瘦素水平，并分析循环瘦素水平与牙周状况之间的关系。
共招募了97例AgP患者和44名健康对照者。进行了详细的临床检查，并记录了出血指数（BI）、探诊深度（PD）、附着丧失（AL）等临床参数。采用酶联免疫吸附测定法测量血浆瘦素水平。
AgP组的血浆瘦素水平显著高于对照组[（20.0±4.3）μg/L对（7.5±1.3）μg/L，P<0.01]。血浆瘦素水平与BI、PD和AL呈正相关，r值分别为0.647、0.596和0.632（P<0.01）。
与健康对照相比，AgP患者的血浆瘦素浓度显著升高。循环瘦素水平与包括BI、PD和AL在内的牙周参数呈正相关。
