Liu Kaining, Meng Huanxin, Tang Xiaolin, Xu Li, Zhang Li, Chen Zhibin, Shi Dong, Feng Xianghui, Lu Ruifang
Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
J Periodontol. 2009 Jul;80(7):1114-20. doi: 10.1902/jop.2009.080675.
Vitamin D is associated with a number of inflammatory diseases and plays a significant role in regulating bone metabolism. Serum calcifediol was demonstrated to be potentially associated with periodontal disease. The purpose of this study was to evaluate whether an association exists between plasma calcifediol concentrations and aggressive periodontitis (AgP) and whether plasma levels of bone-related biomarkers (osteocalcin, alkaline phosphatase, calcium, and phosphorus) regulated by vitamin D are related to AgP.
Sixty-six patients with generalized AgP, 52 patients with chronic periodontitis, and 60 healthy controls were included in this study. Periodontal examination consisted of probing depth, attachment loss, and bleeding index measurements. Hematic calcifediol and bone-related biomarker levels were detected using radioimmunity assay kits or a biochemical analyzer.
Plasma calcifediol levels in patients with AgP were higher than those of healthy controls (29.28 versus 21.60 nmol/l; P <0.05) and were statistically significantly correlated with bleeding index (r = 0.321; P <0.05). Plasma osteocalcin concentrations in patients with AgP were higher than those of healthy controls (0.90 versus 0.70 ng/ml; P <0.05). Serum inorganic phosphorus values of both periodontitis groups were lower than those of healthy controls (1.06 +/- 0.18 mmol/l and 1.10 +/- 0.15 mmol/l versus 1.26 +/- 0.17 mmol/l; P <0.05).
Plasma calcifediol levels might be associated with periodontal inflammation.
维生素D与多种炎症性疾病相关，并在调节骨代谢中发挥重要作用。血清骨化二醇被证明可能与牙周疾病有关。本研究的目的是评估血浆骨化二醇浓度与侵袭性牙周炎（AgP）之间是否存在关联，以及维生素D调节的骨相关生物标志物（骨钙素、碱性磷酸酶、钙和磷）的血浆水平是否与AgP相关。
本研究纳入了66例广泛性AgP患者、52例慢性牙周炎患者和60例健康对照者。牙周检查包括探诊深度、附着丧失和出血指数测量。使用放射免疫分析试剂盒或生化分析仪检测血液中的骨化二醇和骨相关生物标志物水平。
AgP患者的血浆骨化二醇水平高于健康对照者（29.28对21.60 nmol/l；P<0.05），且与出血指数呈显著统计学相关性（r = 0.321；P<0.05）。AgP患者的血浆骨钙素浓度高于健康对照者（0.90对0.70 ng/ml；P<0.05）。两个牙周炎组的血清无机磷值均低于健康对照者（1.06±0.18 mmol/l和1.10±0.15 mmol/l对1.26±0.17 mmol/l；P<0.05）。
血浆骨化二醇水平可能与牙周炎症有关。
