Petrov O V, Bikmulina F S, Vinogradov V L, Fomchenko E P, Smol'nikov P V, Shloznikov B M
Vestn Akad Med Nauk SSSR. 1990(3):5-7.
The antinociceptive effect of dalargin was studied by its influence on the amplitude of somatosensory induced potentials (IP) and by changes in the threshold pain sensitivity to heat stimulation. It was shown that it was necessary to taken into account the patients' individual sensitivity to the drug. The influence of dalargin on IP in the pre-operative period was compared with the quality of its analgetic defence in surgical interventions. The defence quality was determined according to the reduction in the consumption of the narcotic analgesic phentanyl during anesthesia. The studied parameters were found to be directly related to the correlation coefficient 0.75 (p less than 0.05). The findings allow for a reliable prediction of the antinociceptive effect of dalargin in its application in anaesthesiological practice.
通过研究达拉argin对体感诱发电位（IP）幅度的影响以及热刺激痛觉阈值的变化，来探讨其镇痛作用。结果表明，有必要考虑患者对该药物的个体敏感性。将达拉argin在术前对IP的影响与其在手术干预中的镇痛效果进行了比较。镇痛效果根据麻醉期间麻醉性镇痛药芬太尼消耗量的减少来确定。研究参数与相关系数0.75直接相关（p小于0.05）。这些发现使得能够可靠地预测达拉argin在麻醉实践中的镇痛效果。
