Shloznikov B M, Donich S G, Grebenchikova O A, Makhmutov R F, Likhvantsev V V, Kuznetsov A Iu, Peretrukin A I, Fomchenkov E P
Biull Eksp Biol Med. 1990 Mar;109(3):272-5.
The antinociceptive properties of dalargin (D) under nembutal anesthesia and artificial ventilation were studied in hemodynamic response to mechanical algesic stimulation in rats. D was introduced i/v (20 micrograms/kg) against a background of myoplegia with Arduan (0.1 mg/kg) and without it. The naloxon (100 micrograms/kg) prevented the protective effects of D. It is considered that injection of D (20 micrograms/kg) on the background of total myoplegia and artificial ventilation prevented hemodynamic response on algesic stimulus. Subsequent dose increase of opium peptide up to 3500 micrograms/kg does not cause amplification of protective properties.
在戊巴比妥麻醉和人工通气条件下，研究了达拉argin（D）对大鼠机械性伤害性刺激的血流动力学反应的抗伤害感受特性。在使用阿端（0.1mg/kg）导致肌麻痹的背景下和无此背景下，静脉注射D（20微克/千克）。纳洛酮（100微克/千克）可阻止D的保护作用。据认为，在完全肌麻痹和人工通气背景下注射D（20微克/千克）可防止对伤害性刺激的血流动力学反应。随后将阿片肽剂量增加至3500微克/千克并不会增强保护特性。
