Cylwik Bogdan, Naklicki Marcin, Gruszewska Ewa, Szmitkowski Maciej, Chrostek Lech
Department of Biochemical Diagnostics, Medical University of Bialystok, Bialystok, Poland.
J Nutr Sci Vitaminol (Tokyo). 2013;59(1):1-8. doi: 10.3177/jnsv.59.1.
Chronic alcohol consumption leads to malnutrition and to the deficiency of many vitamins. One of the most important is folate deficiency. Folate deficiency disrupts the process of hematopoiesis, which can be evaluated by the changes of red cell indices. The aim of this study was to determine the hematological disturbances by the measurement of red blood cell indices in a Polish population of chronic alcoholics according to folate status. We studied 80 consecutive chronic alcoholic men and 30 healthy controls. Patients were divided into 2 groups according to the folate concentration. The serum folate and vitamin B12 concentration and the blood count were determined. We have shown that the serum folate concentration was decreased in 40% of alcoholics, but there was no folate deficiency and the level of vitamin B12 was normal. There was no correlation between folate, vitamin B12 and hematological indices. We have observed that most hematological parameters (Hb, RBCs, and Hct) in alcoholics were decreased and only two of them (MCV and MCHC) were increased in comparison with the controls. We observed no significant correlation between the RBCs indices and the weekly alcohol intake, but the correlation between RBCs, Hb, Hct and the duration of dependence have been shown. We concluded that, there is no folate deficiency in the Polish alcoholic population but the abusers with low folate levels may already have some RBCs indices affected. It means that the Polish alcoholic population consumes a sufficient amount of vitamins, which prevents the occurrence of hematological disturbances.
长期饮酒会导致营养不良和多种维生素缺乏。其中最重要的一种是叶酸缺乏。叶酸缺乏会扰乱造血过程，这可以通过红细胞指数的变化来评估。本研究的目的是根据叶酸状态，通过测量波兰慢性酗酒人群的红细胞指数来确定血液学紊乱情况。我们研究了80名连续的慢性酗酒男性和30名健康对照者。根据叶酸浓度将患者分为2组。测定了血清叶酸和维生素B12浓度以及血细胞计数。我们发现40%的酗酒者血清叶酸浓度降低，但不存在叶酸缺乏且维生素B12水平正常。叶酸、维生素B12与血液学指标之间无相关性。我们观察到，与对照组相比，酗酒者的大多数血液学参数（血红蛋白、红细胞和血细胞比容）降低，只有其中两项（平均红细胞体积和平均红细胞血红蛋白浓度）升高。我们未观察到红细胞指数与每周饮酒量之间存在显著相关性，但红细胞、血红蛋白、血细胞比容与依赖持续时间之间存在相关性。我们得出结论，波兰酗酒人群不存在叶酸缺乏，但叶酸水平低的酗酒者可能已经有一些红细胞指数受到影响。这意味着波兰酗酒人群摄入了足够的维生素，从而预防了血液学紊乱的发生。
