Azimi Sona, Faramarzi Elnaz, Sarbakhsh Parvin, Ostadrahimi Alireza, Somi Mohammad Hossein, Ghayour Mousa
1 Nutrition Research Center, Tabriz University of Medical Sciences, Iran.
2 Nutrition, Liver and Gastrointestinal Disease Research Center, Tabriz University of Medical Sciences, Iran.
Nutr Health. 2019 Mar;25(1):29-36. doi: 10.1177/0260106018815392. Epub 2018 Dec 28.
: Folate and vitamin B are essential micronutrients, the deficiency of which can be associated with public health problems worldwide.
: The aims of this study were to assess the folate and vitamin B status of healthy adults and the effect of gender differences on their deficiency using serum folate, vitamin B and red blood cell (RBC) folate as biomarkers and their relation to hematological indices.
: This study was a part of the Azar cohort study, which is designed as a noncommunicable disease survey in the population of Shabestar, East Azerbaijan, Iran. A total of 95 healthy adults (35 men, 60 women) were chosen according to exclusion criteria and assessed using demographic characteristics and blood sampling.
: Low concentrations of serum folate, vitamin B and RBC folate were detected in 16.8%, 61.1% and 40% of all subjects, respectively. Prevalence of low serum folate and vitamin B was higher in men than women (25.7% versus 11.7% for serum folate, 77.1% versus 51.7% for serum vitamin B).A significant positive correlation was found between hemoglobin and serum folate, vitamin B and RBC folate concentrations ( r = 0.279, 0.335, 0.228, respectively). No statistically significant correlation between mean corpuscular volume and serum folate, vitamin B and RBC folate was seen ( r = -0.049, -0.030, -0.016, respectively).
: There was a high prevalence of low folate and vitamin B concentrations in our community. Regarding the impact of these two vitamins deficiency on overall health, we suggest further investigations with more participants. In addition, monitoring hematological indices could be useful in people with folate and vitamin B deficiency.
叶酸和维生素B是必需的微量营养素，其缺乏可能与全球范围内的公共卫生问题相关。
本研究旨在以血清叶酸、维生素B和红细胞（RBC）叶酸作为生物标志物，评估健康成年人的叶酸和维生素B状态以及性别差异对其缺乏情况的影响，及其与血液学指标的关系。
本研究是阿扎尔队列研究的一部分，该研究旨在对伊朗东阿塞拜疆省沙贝斯塔的人群进行非传染性疾病调查。根据排除标准共选取了95名健康成年人（35名男性，60名女性），并通过人口统计学特征和血液采样进行评估。
在所有受试者中，分别有16.8%、61.1%和40%的人血清叶酸、维生素B和红细胞叶酸浓度较低。男性血清叶酸和维生素B缺乏的患病率高于女性（血清叶酸为25.7%对11.7%，血清维生素B为77.1%对51.7%）。血红蛋白与血清叶酸、维生素B和红细胞叶酸浓度之间存在显著正相关（r分别为0.279、0.335、0.228）。平均红细胞体积与血清叶酸、维生素B和红细胞叶酸之间未发现统计学显著相关性（r分别为-0.049、-0.030、-0.016）。
我们社区中叶酸和维生素B浓度低的患病率很高。鉴于这两种维生素缺乏对整体健康的影响，我们建议进行更多参与者的进一步调查。此外，监测血液学指标对叶酸和维生素B缺乏的人可能有用。
