Paaby P O, Nielsen A, Raffn K
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Acta Endocrinol (Copenh). 1990 May;122(5):617-22. doi: 10.1530/acta.0.1220617.
Eleven healthy women were examined three times a week during the third trimester. The possibility of monthly cyclical changes in the serum concentrations of cortisol, placental hCG and fetoplacental estradiol was tested because of previous findings of highly significant monthly cycles in aldosterone and progesterone. A semiparametric statistical model was used and a highly significant monthly cycle in serum cortisol was found, whereas the amplitude for a cycle in hCG was barely significant and non-significant for estradiol. The previous findings of monthly cycles in aldosterone and progesterone, using a parametric multivariate model, were retested by the semiparametric method employed for the present publication. The findings of highly significant cycles in aldosterone and progesterone were corroborated. We think that the results indicate the existence of an adrenocortical cycle. We think that the monthly ovarian cycle in the non-pregnant state is paralleled by an adrenocortical cycle, where changes in aldosterone are "linked" with changes in progesterone and changes in cortisol with changes in estrogens. During pregnancy the adrenocortical cycle persists, probably controlled by the maternal hypothalamus. The physiological background for this monthly endocrine cycle during pregnancy is enigmatic.
在妊娠晚期，对11名健康女性每周进行三次检查。鉴于之前发现醛固酮和孕酮存在高度显著的月度周期变化，因此对皮质醇、胎盘人绒毛膜促性腺激素（hCG）和胎儿 - 胎盘雌二醇血清浓度的月度周期性变化可能性进行了测试。使用了半参数统计模型，发现血清皮质醇存在高度显著的月度周期，而hCG的周期幅度勉强显著，雌二醇则无显著周期。使用参数多元模型先前得出的醛固酮和孕酮月度周期的结果，通过本出版物采用的半参数方法进行了重新测试。醛固酮和孕酮高度显著周期的结果得到了证实。我们认为这些结果表明存在肾上腺皮质周期。我们认为非妊娠状态下的月度卵巢周期与肾上腺皮质周期并行，其中醛固酮的变化与孕酮的变化“相关”，皮质醇的变化与雌激素的变化相关。在怀孕期间，肾上腺皮质周期持续存在，可能受母体下丘脑控制。怀孕期间这种月度内分泌周期的生理背景尚不清楚。
