Paaby P, Nielsen A, Raffn K
Department of Clinical Chemistry, Aalborg Hospital, Denmark.
Acta Endocrinol (Copenh). 1989 May;120(5):636-43. doi: 10.1530/acta.0.1200636.
Eleven healthy women were examined three times a week during the third trimester. A mathematical model (parabolas overlaid with a cosine curve and containing parameters for cycle length, cycle amplitude and phase) was used in a multivariate analysis of changes in serum progesterone, serum aldosterone, serum osmolality and urinary potassium. A highly significant monthly cycle in progesterone and aldosterone and a significant cycle in the urinary excretion rate of potassium were found. The individual rates of increase in serum progesterone and serum aldosterone were different and uncorrelated, and in the monthly cycle there was a phase difference between them. We think that the changes in serum progesterone and serum aldosterone are controlled by different stimuli and that the control of the cyclical component originates in the maternal neuro-endocrine system.
11名健康女性在孕晚期接受每周3次的检查。在对血清孕酮、血清醛固酮、血清渗透压和尿钾变化进行的多变量分析中，使用了一个数学模型（叠加有余弦曲线且包含周期长度、周期幅度和相位参数的抛物线）。发现孕酮和醛固酮有高度显著的月度周期，钾的尿排泄率有显著周期。血清孕酮和血清醛固酮的个体升高速率不同且不相关，在月度周期中它们之间存在相位差异。我们认为血清孕酮和血清醛固酮的变化受不同刺激控制，且周期性成分的控制源自母体神经内分泌系统。
