Kinnunen E, Juntunen J, Konttinen Y, Kemppinen P, Ketonen L, Kleemola M, Valle M, Koskimies S, Koskenvuo M
Clinical Neurosciences, Institute of Occupational Health, Helsinki, Finland.
Acta Neurol Scand. 1990 Mar;81(3):246-9. doi: 10.1111/j.1600-0404.1990.tb00976.x.
During a nationwide twin study on multiple sclerosis (MS) in Finland a dizygotic pair discordant for MS was found. The affected co-twin had dizygotic twin daughters. The affected co-twin of the second generation had systemic lupus erythematosus (SLE). Both pairs were thoroughly examined. No evidence of CNS involvement in the healthy co-twins was found. In pairwise comparisons, virus-specific IgG antibodies to measles and mumps were significantly increased in the MS patient whereas the same was true for rubella in the SLE patient. Both MS and SLE patient expressed HLA alleles most often found to be associated with these disorders. Reversed CD4/CD8 ratios were observed in both MS and SLE patient. No difference in interleukin-2 receptor expression were found but gamma-interferon secretion in the MS patient showed marked increase whereas that of the SLE patient was of the same magnitude as in the healthy members. A different triggering stimulus rather than the dissimilarity in the immunogenetic predisposition may be decisive as to whether or not they develop MS or SLE.
在芬兰一项关于多发性硬化症（MS）的全国性双胞胎研究中，发现了一对患MS的异卵双胞胎。患病的双胞胎有一对异卵双胞胎女儿。第二代患病的双胞胎患有系统性红斑狼疮（SLE）。对这两对双胞胎都进行了全面检查。未发现健康的双胞胎有中枢神经系统受累的迹象。在成对比较中，MS患者针对麻疹和风疹的病毒特异性IgG抗体显著增加，而SLE患者中针对风疹的病毒特异性IgG抗体显著增加。MS和SLE患者均表达了最常发现与这些疾病相关的HLA等位基因。MS和SLE患者均观察到CD4/CD8比值倒置。未发现白细胞介素-2受体表达存在差异，但MS患者的γ-干扰素分泌显著增加，而SLE患者的γ-干扰素分泌水平与健康成员相同。对于他们是否会患上MS或SLE，不同的触发刺激而非免疫遗传易感性的差异可能起决定性作用。
