Woyciechowska J L, Dambrozia J, Leinikki P, Shekarchi C, Wallen W, Sever J, McFarland H, McFarlin D
Neurology. 1985 Aug;35(8):1176-80. doi: 10.1212/wnl.35.8.1176.
Viral antibodies to measles, rubella, corona, vaccinia, and mumps viruses in serum and CSF (and to Epstein-Barr virus in serum only) were studied in 24 twin pairs, both discordant and concordant for clinical MS. In pairs, CSF antibody titers for rubella in MS monozygotic and dizygotic twins and for vaccinia in dizygotic twins were higher than for unaffected twins. Increased CSF titers among MS twins existed for measles, rubella, and vaccinia when pairing was ignored. Among MS twins, serum rubella and measles and CSF measles antibody titers, and CSF:serum ratios for measles virus, were higher in those who were DW2 positive.
在24对临床多发性硬化症（MS）症状有差异和无差异的双胞胎中，研究了血清和脑脊液中针对麻疹、风疹、冠状病毒、牛痘和腮腺炎病毒的病毒抗体（仅血清中针对爱泼斯坦 - 巴尔病毒的抗体）。在这些双胞胎对中，MS单卵双胞胎和风疹双卵双胞胎的脑脊液风疹抗体滴度以及双卵双胞胎的脑脊液牛痘抗体滴度高于未患病的双胞胎。若不考虑配对情况，MS双胞胎中麻疹、风疹和牛痘的脑脊液滴度升高。在MS双胞胎中，DW2阳性者的血清风疹和麻疹、脑脊液麻疹抗体滴度以及麻疹病毒的脑脊液与血清比值更高。
