Ear, Nose and Throat Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Eur Arch Otorhinolaryngol. 2013 Nov;270(12):3095-8. doi: 10.1007/s00405-013-2449-5. Epub 2013 Mar 28.
Allergic fungal sinusitis (AFS) is a noninvasive form of fungal rhinosinusitis with a prevalence of 6-9 % among all rhinosinusitis cases requiring surgery. The fungi causing AFRS have a great diversity and regional variation in the incidence of AFS has been reported worldwide. The aim of this study was to evaluate the prevalence of AFS among rhinosinusitis patients in the north east of Iran. In a prospective cross-sectional study 127 patients with sinonasal polyposis who were candidates for surgery were recruited. All cases were evaluated by sinonasal CT scan, Prick test for common regional allergens, total serum immunoglobulin E (IgE) level, and allergic mucin culture for fungi in suspected cases. Data analyses were done using SPSS version 13.0. Their mean age was 37.4 ± 11.6 years, the male-to-female ratio was 69/58. Eleven patients (9.45 %) met the AFS criteria. Nine cases had a positive culture for Aspergillus specimen and three for Alternaria. Prick test was positive for at least one allergen in 28 cases (22.05 %). The most common allergen was weed. The total IgE level was significantly higher in AFS patients. This study showed the prevalence of AFS among patients with nasal polyposis to be 9.45 %.
变应性真菌性鼻旁窦炎（AFS）是一种非侵袭性真菌性鼻旁窦炎，在需要手术的所有鼻旁窦炎病例中，其患病率为 6-9%。引起 AFS 的真菌种类繁多，世界各地均有报道 AFS 的发病率存在地区差异。本研究旨在评估伊朗东北部鼻旁窦炎患者中 AFS 的患病率。在一项前瞻性横断面研究中，招募了 127 名患有鼻息肉并需要手术的患者。所有病例均通过鼻旁窦 CT 扫描、常见区域过敏原皮试、总血清免疫球蛋白 E（IgE）水平以及疑似病例的真菌过敏粘蛋白培养进行评估。数据分析使用 SPSS 版本 13.0 进行。他们的平均年龄为 37.4 ± 11.6 岁，男女比例为 69/58。11 名患者（9.45%）符合 AFS 标准。9 例培养出曲霉菌标本阳性，3 例培养出交链孢霉阳性。28 例皮试至少有一种过敏原阳性。最常见的过敏原是杂草。AFS 患者的总 IgE 水平明显更高。本研究显示，鼻息肉患者中 AFS 的患病率为 9.45%。
