Jiao Xu-guang, Liang Han, Deng Jing-yu, Wang Li, Liu Hong-gen, Liang Yue-xiang
Department of Gastrointestinal Oncology Surgery, Key Lab of Cancer Treatment and Prevention, Tianjin Cancer Hospital, Tianjin Medical University, Tianjin 300060, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2013 Mar;16(3):260-3.
To evaluate the clinicopathologic characteristics and prognosis of mixed histological type (MHT) gastric cancer.
Clinical and follow-up data of 1108 gastric cancer patients undergoing radical operation in Tianjin Cancer Hospital between 2003 and 2006 were analyzed retrospectively. Clinicopathologic characteristics of MHT gastric cancer were summarized and the prognosis was analyzed by Kaplan-Meier analysis and COX regression.
Among the 1108 patients, 144 (13.0%) had mixed histology type of gastric cancer. Compared to the unitary histological type (UHT), MHT gastric cancer had bigger tumor size, higher proportion of T4 tumor, and was easier for lymph node and distant metastasis (all P<0.05). The 3- and 5-year survival rates of patients with MHT were 26.5% and 10.8% respectively, which were lower than those with UHT (58.8% and 35.0%, P<0.01). Univariate and multivariate analyses showed TNM classification was an independent prognostic factor (P<0.01).
MHT gastric cancer shows worse prognosis than UHT gastric cancer. There is no difference in prognosis among various combination of MHT gastric cancer. TNM classification is an independent prognostic factor of MHT gastric cancer.
评估混合组织学类型（MHT）胃癌的临床病理特征及预后。
回顾性分析2003年至2006年在天津医科大学肿瘤医院接受根治性手术的1108例胃癌患者的临床及随访资料。总结MHT胃癌的临床病理特征，并采用Kaplan-Meier分析和COX回归分析预后。
1108例患者中，144例（13.0%）为混合组织学类型胃癌。与单一组织学类型（UHT）相比，MHT胃癌肿瘤体积更大，T4期肿瘤比例更高，更容易发生淋巴结转移和远处转移（均P<0.05）。MHT患者的3年和5年生存率分别为26.5%和10.8%，低于UHT患者（58.8%和35.0%，P<0.01）。单因素和多因素分析显示TNM分期是独立的预后因素（P<0.01）。
MHT胃癌的预后比UHT胃癌差。MHT胃癌不同组合之间的预后无差异。TNM分期是MHT胃癌的独立预后因素。
