Shao Chang-ming, Shao Qin-shu, Yao Hai-bo, Zhao Zhong-kuo, Xu Ji, Zhao Zhong-sheng, Tao Hou-quan
Department of Surgery, Zhejiang Provincial People's Hospital, Hangzhou, China.
Zhonghua Wei Chang Wai Ke Za Zhi. 2012 Jul;15(7):736-9.
To investigate the association of SOX9 expression and clinicopathologic factors and prognosis of gastric cancer.
A retrospective cohort study including 112 gastric cancer patients admitted to the Zhejiang Provincial People's Hospital from 2004 to 2006 was performed. Immunohistochemical analysis was used to evaluate the expression of SOX9 in the 112 specimens of gastric cancer tissues and 70 non-cancerous tissues adjacent to the tumor.
Low expression of SOX9 was seen in 5(7.1%) tissues out of 70 non-cancerous tissues adjacent to the tumor. A total of 94(83.9%) patients had varying expression of SOX9, of whom 51(45.4%) had overexpression. Univariate analysis demonstrated that the expression of SOX9 was significantly associated with Lauren classification (P<0.05), tumor invasion(P<0.01), lymph node metastasis(P<0.05), distant metastasis(P<0.05) and tumor stage(P<0.05), however there was no significant association between SOX9 expression and sex, age, histological type, histology differentiation or tumor size. Kaplan-Meier analysis showed that the 5-year survival rate of patients with SOX9 over-expression was significantly lower than that of patients with low expression(29.4% vs. 49.2%, P=0.031). Multivariate Cox regression analysis showed that histology differentiation(P=0.046), tumor invasion(P=0.001), and distant metastasis(P<0.01) were independent prognostic factors for gastric cancer, however the over-expression of SOX9 was not significant(P=0.948).
The expression SOX9 is associated with the growth, invasion, and metastasis of gastric cancer, as well as the prognosis. However, SOX9 expression is not an independent factor for the prognosis in patients with gastric cancer.
探讨SOX9表达与胃癌临床病理因素及预后的关系。
进行一项回顾性队列研究，纳入2004年至2006年在浙江省人民医院收治的112例胃癌患者。采用免疫组织化学分析评估112例胃癌组织标本及70例肿瘤旁非癌组织中SOX9的表达。
70例肿瘤旁非癌组织中5例（7.1%）组织SOX9低表达。共94例（83.9%）患者SOX9有不同程度表达，其中51例（45.4%）过表达。单因素分析显示，SOX9表达与Lauren分型（P<0.05）、肿瘤浸润（P<0.01）、淋巴结转移（P<0.05）、远处转移（P<0.05）及肿瘤分期（P<0.05）显著相关，然而SOX9表达与性别、年龄、组织学类型、组织学分化或肿瘤大小无显著关联。Kaplan-Meier分析显示，SOX9过表达患者的5年生存率显著低于低表达患者（29.4%对49.2%，P=0.031）。多因素Cox回归分析显示，组织学分化（P=0.046）、肿瘤浸润（P=0.001）及远处转移（P<0.01）是胃癌的独立预后因素，然而SOX9过表达无显著意义（P=0.948）。
SOX9表达与胃癌的生长、浸润、转移及预后相关。然而，SOX9表达不是胃癌患者预后的独立因素。
