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本文引用的文献

1
Treatment of knee joint osteoarthritis with autologous platelet-rich plasma in comparison with hyaluronic acid.自体富血小板血浆与透明质酸治疗膝关节骨关节炎的比较。
Am J Phys Med Rehabil. 2012 May;91(5):411-7. doi: 10.1097/PHM.0b013e3182aab72.
2
Injection of platelet-rich plasma in patients with primary and secondary knee osteoarthritis: a pilot study.富血小板血浆注射治疗原发性和继发性膝骨关节炎患者：一项初步研究。
Am J Phys Med Rehabil. 2010 Dec;89(12):961-9. doi: 10.1097/PHM.0b013e3181fc7edf.
3
Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee.富含血小板血浆与可生物降解明胶水凝胶微球关节内给药可预防兔膝关节骨关节炎进展。
Clin Exp Rheumatol. 2009 Mar-Apr;27(2):201-7.
4
Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study.关节内注射富含生长因子的自体制剂治疗膝骨关节炎：一项回顾性队列研究。
Clin Exp Rheumatol. 2008 Sep-Oct;26(5):910-3.
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Influence of platelet-rich plasma on chondrogenic differentiation and proliferation of chondrocytes and mesenchymal stem cells.富血小板血浆对软骨细胞和间充质干细胞软骨形成分化及增殖的影响。
Cells Tissues Organs. 2009;189(5):317-26. doi: 10.1159/000151290. Epub 2008 Aug 11.
6
Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis.自体浓缩生长因子（Orthokine）是治疗膝关节骨关节炎的一种有效疗法。
Osteoarthritis Cartilage. 2009 Feb;17(2):152-60. doi: 10.1016/j.joca.2008.06.014. Epub 2008 Jul 31.
7
Platelet-released growth factors enhance the secretion of hyaluronic acid and induce hepatocyte growth factor production by synovial fibroblasts from arthritic patients.血小板释放的生长因子可增强透明质酸的分泌，并诱导关节炎患者滑膜成纤维细胞产生肝细胞生长因子。
Rheumatology (Oxford). 2007 Dec;46(12):1769-72. doi: 10.1093/rheumatology/kem234. Epub 2007 Oct 17.
8
Cyclooxygenase-2 selectivity of non-steroidal anti-inflammatory drugs and the risk of myocardial infarction and cerebrovascular accident.非甾体抗炎药的环氧化酶-2选择性与心肌梗死和脑血管意外风险
Aliment Pharmacol Ther. 2007 Apr 15;25(8):913-24. doi: 10.1111/j.1365-2036.2007.03292.x.
9
Pro- and anti-inflammatory cytokine content in human peripheral blood after its transcutaneous (in vivo) and direct (in vitro) irradiation with polychromatic visible and infrared light.人体外周血经多色可见光和红外光经皮（体内）及直接（体外）照射后的促炎和抗炎细胞因子含量。
Photomed Laser Surg. 2006 Apr;24(2):129-39. doi: 10.1089/pho.2006.24.129.
10
Longterm effects of intraarticular hyaluronan on synovial fluid in osteoarthritis of the knee.关节内注射透明质酸对膝骨关节炎滑液的长期影响。
J Rheumatol. 2006 May;33(5):946-50.

评估光激活疗法联合富血小板血浆注射对骨关节炎新治疗方法的效果。

To evaluate the effect of combining photo-activation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis.

作者信息

Freitag Julien Ben, Barnard Adele

机构信息

Prahran Sports Medicine Centre, Lifecare, Prahran, Victoria, Australia.

出版信息

BMJ Case Rep. 2013 Mar 26;2013:bcr2012007463. doi: 10.1136/bcr-2012-007463.

DOI:10.1136/bcr-2012-007463
PMID:23536619
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3618722/
Abstract

OBJECTIVE

To evaluate the effect of combining photo-activation therapy with platelet-rich plasma injections for the novel treatment of osteoarthritis.

DESIGN

We present a case report of osteoarthritis of the knee treated with photo-activated platelet-rich plasma injections (PAPRP).

METHODS

After utilising conventional osteoarthritis treatment methods a patient underwent a course of PAPRP injections. The patient outcome was measured using the numerical pain rating scale (NPRS) and the Western Ontario and McMaster Universities Arthritis (WOMAC) Index.

RESULTS

Following treatment the patient reported improvements in both pain and function as measured by the NPRS and WOMAC Index, respectively. The patient was followed up for 18 weeks, at which time no significant complications were noted.

CONCLUSIONS

In this case report of osteoarthritis, with strict control of conventional therapy variables, PAPRP injections demonstrated improvement in all recorded outcome measures. The results of this case report highlight the need to further investigate the use of PAPRP in the treatment of symptomatic knee osteoarthritis.

摘要

目的

评估光激活疗法联合富血小板血浆注射对骨关节炎的新型治疗效果。

设计

我们呈现了一例采用光激活富血小板血浆注射（PAPRP）治疗膝骨关节炎的病例报告。

方法

在使用传统骨关节炎治疗方法后，一名患者接受了一个疗程的PAPRP注射。使用数字疼痛评分量表（NPRS）和西安大略和麦克马斯特大学骨关节炎指数（WOMAC）对患者的治疗效果进行评估。

结果

治疗后，患者分别通过NPRS和WOMAC指数报告了疼痛和功能的改善。对患者进行了18周的随访，在此期间未发现明显并发症。

结论

在本骨关节炎病例报告中，在严格控制传统治疗变量的情况下，PAPRP注射在所有记录的疗效指标上均显示出改善。本病例报告的结果凸显了进一步研究PAPRP在有症状膝骨关节炎治疗中应用的必要性。