60 岁以上人群中 EBV 阴性与 HLA-C 和 HLA-Bw4 变体及扁桃体切除术相关。
Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy.
机构信息
Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
出版信息
J Virol. 2013 Jun;87(11):6526-9. doi: 10.1128/JVI.00169-13. Epub 2013 Mar 27.
Abstract
Epstein-Barr virus (EBV) infects ≈ 95% of the adult population. The factors that confer protection in the remaining ≈ 5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 years. Analyses of HLA genotypes revealed an association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4 alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more often than EBV-positive donors.
摘要
EB 病毒（EBV）感染了约 95%的成年人。而其余约 5%的人具有保护作用的因素仍不清楚。在一项探索性研究中，我们评估了 17 名 EBV 阴性和 39 名 EBV 阳性的年龄>60 岁的健康个体的免疫遗传因素和扁桃体切除术。HLA 基因型分析显示，HLA-C-35T/T 和/或 HLA-Bw4 等位基因的存在与 EBV 阴性有关。此外，EBV 阴性供体比 EBV 阳性供体更常接受过扁桃体切除术。
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