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本文引用的文献

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KIR-HLA and maternal-infant HIV-1 transmission in sub-Saharan Africa.KIR-HLA 与撒哈拉以南非洲的母婴 HIV-1 传播。
PLoS One. 2011 Feb 8;6(2):e16541. doi: 10.1371/journal.pone.0016541.
2
HLA-C cell surface expression and control of HIV/AIDS correlate with a variant upstream of HLA-C.HLA-C 细胞表面表达与 HIV/AIDS 的控制与 HLA-C 上游的一个变异体相关。
Nat Genet. 2009 Dec;41(12):1290-4. doi: 10.1038/ng.486.
3
KIR-HLA intercourse in HIV disease.HIV疾病中的杀伤细胞免疫球蛋白样受体-人类白细胞抗原相互作用
Trends Microbiol. 2008 Dec;16(12):620-7. doi: 10.1016/j.tim.2008.09.002. Epub 2008 Oct 29.
4
A combined genotype of KIR3DL1 high expressing alleles and HLA-B*57 is associated with a reduced risk of HIV infection.KIR3DL1高表达等位基因与HLA - B*57的联合基因型与降低HIV感染风险相关。
AIDS. 2008 Jul 31;22(12):1487-91. doi: 10.1097/QAD.0b013e3282ffde7e.
5
Increased proportion of KIR3DS1 homozygotes in HIV-exposed uninfected individuals.暴露于HIV但未感染个体中KIR3DS1纯合子比例增加。
AIDS. 2008 Mar 12;22(5):595-9. doi: 10.1097/QAD.0b013e3282f56b23.
6
Tonsilar NK cells restrict B cell transformation by the Epstein-Barr virus via IFN-gamma.扁桃体自然杀伤细胞通过γ干扰素限制爱泼斯坦-巴尔病毒引起的B细胞转化。
PLoS Pathog. 2008 Feb 8;4(2):e27. doi: 10.1371/journal.ppat.0040027.
7
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.HLA - B与KIR3DL1亚型针对HIV - 1的固有协同作用。
Nat Genet. 2007 Jun;39(6):733-40. doi: 10.1038/ng2035. Epub 2007 May 13.
8
HIV patients developing primary CNS lymphoma lack EBV-specific CD4+ T cell function irrespective of absolute CD4+ T cell counts.感染人类免疫缺陷病毒（HIV）并发展为原发性中枢神经系统淋巴瘤的患者，无论其CD4+T细胞绝对计数如何，均缺乏EB病毒特异性CD4+T细胞功能。
PLoS Med. 2007 Mar 27;4(3):e96. doi: 10.1371/journal.pmed.0040096.
9
Cutting edge: resistance to HIV-1 infection among African female sex workers is associated with inhibitory KIR in the absence of their HLA ligands.前沿：非洲女性性工作者对HIV-1感染的抗性与缺乏HLA配体时的抑制性杀伤细胞免疫球蛋白样受体相关。
J Immunol. 2006 Nov 15;177(10):6588-92. doi: 10.4049/jimmunol.177.10.6588.
10
Roles for HLA and KIR polymorphisms in natural killer cell repertoire selection and modulation of effector function.HLA和KIR基因多态性在自然杀伤细胞库选择及效应功能调节中的作用。
J Exp Med. 2006 Mar 20;203(3):633-45. doi: 10.1084/jem.20051884. Epub 2006 Mar 13.

60 岁以上人群中 EBV 阴性与 HLA-C 和 HLA-Bw4 变体及扁桃体切除术相关。

Epstein-Barr virus negativity among individuals older than 60 years is associated with HLA-C and HLA-Bw4 variants and tonsillectomy.

机构信息

Immunobiology Laboratory, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.

出版信息

J Virol. 2013 Jun;87(11):6526-9. doi: 10.1128/JVI.00169-13. Epub 2013 Mar 27.

DOI:10.1128/JVI.00169-13
PMID:23536655
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3648112/
Abstract

Epstein-Barr virus (EBV) infects ≈ 95% of the adult population. The factors that confer protection in the remaining ≈ 5% remain unknown. In an exploratory study, we assessed immunogenetic factors and tonsillectomy in a cohort of 17 EBV-negative and 39 EBV-positive healthy individuals aged >60 years. Analyses of HLA genotypes revealed an association between EBV negativity and the presence of HLA-C-35T/T and/or HLA-Bw4 alleles. In addition, EBV-negative donors presented with a history of tonsillectomy more often than EBV-positive donors.

摘要

EB 病毒（EBV）感染了约 95%的成年人。而其余约 5%的人具有保护作用的因素仍不清楚。在一项探索性研究中，我们评估了 17 名 EBV 阴性和 39 名 EBV 阳性的年龄>60 岁的健康个体的免疫遗传因素和扁桃体切除术。HLA 基因型分析显示，HLA-C-35T/T 和/或 HLA-Bw4 等位基因的存在与 EBV 阴性有关。此外，EBV 阴性供体比 EBV 阳性供体更常接受过扁桃体切除术。