Singapore Eye Research Institute and Singapore National Eye Centre, Singapore.
Invest Ophthalmol Vis Sci. 2013 Apr 23;54(4):2829-35. doi: 10.1167/iovs.12-11250.
We determined the ocular biometric and demographic factors associated with iris parameters in Singaporean Chinese persons from a population-based sample.
Subjects were participants in the Singapore Chinese Eye Study, a population-based cross-sectional study of eye disease. Anterior segment optical coherence tomography images were analyzed using customized software to measure iris thickness at 750 μm from the scleral spur (IT750), iris area (I-Area), and iris curvature (I-Curv). Regression analyses were performed to assess the association between iris measurements with a range of demographic and ocular variables. The contribution of each independent variable to the iris parameter of interest was determined sequentially using a stepwise selection algorithm.
We included 1473 participants with a mean age of 57.7 + 8.68 years, and 50.6% were men. The mean IT750, I-Area, and I-Curv were 0.46 ± 0.10 mm, 1.49 ± 0.24 mm(2), and 0.25 ± 0.13 mm, respectively. Statistical regression models, including a range of demographic and ocular parameters, explained 59.3%, 41.9%, and 34.3% of the variability in I-Curv, IT750, and I-Area, respectively. Angle opening distance at 750 μm from the scleral spur (AOD750) was the single factor associated most strongly with I-Curv, and explained 46.6% of its variation.
A significant proportion of the variation in iris area, curvature, and thickness was not explained by other ocular and demographic parameters. Iris curvature was associated strongly with angle width, and of all parameters investigated, AOD750 was most highly correlated with iris curvature.
我们从基于人群的样本中确定了与新加坡华人眼睛虹膜参数相关的眼部生物测量和人口统计学因素。
受试者是新加坡华人眼睛研究的参与者，这是一项基于人群的眼部疾病横断面研究。使用定制软件对眼前节光学相干断层扫描图像进行分析，以测量巩膜突（IT750）、虹膜面积（I-Area）和虹膜曲率（I-Curv）处 750μm 处的虹膜厚度。进行回归分析以评估虹膜测量值与各种人口统计学和眼部变量之间的关系。使用逐步选择算法依次确定每个独立变量对感兴趣的虹膜参数的贡献。
我们纳入了 1473 名平均年龄为 57.7 + 8.68 岁的参与者，其中 50.6%为男性。平均 IT750、I-Area 和 I-Curv 分别为 0.46 ± 0.10mm、1.49 ± 0.24mm(2)和 0.25 ± 0.13mm。包含一系列人口统计学和眼部参数的统计回归模型分别解释了 I-Curv、IT750 和 I-Area 变异性的 59.3%、41.9%和 34.3%。巩膜突 750μm 处的开口距离（AOD750）是与 I-Curv 相关性最强的单一因素，解释了其变异的 46.6%。
虹膜面积、曲率和厚度的变化很大一部分不能用其他眼部和人口统计学参数来解释。虹膜曲率与角度宽度密切相关，在所研究的所有参数中，AOD750 与虹膜曲率相关性最高。
