Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Science, Beijing Tongren Hospital, Capital Medical University; Beijing, China.
Beijing Institute of Ophthalmology, Beijing, China.
Invest Ophthalmol Vis Sci. 2023 Jan 3;64(1):8. doi: 10.1167/iovs.64.1.8.
To investigate the anterior segment characteristics of primary angle closure disease (PACD) with long axial length (AL) compared with that of those with short and medium AL and explore the risk factors associated with AC with different AL levels.
This observational cross-sectional study enrolled subjects aged 35 years or older who completed the follow-up examinations of the Handan Eye Study and dichotomized them into normal and PACD groups. Ocular data of the right eye were analyzed. AL was categorized into short (<22.0 mm), medium (22.0-24.0 mm), or long (>24.0 mm) subgroups. Demographic and anterior segment parameters of PACD subjects were compared between the three AL subgroups. Logistic regression analysis was performed to identify the risk factors for PACD in the three subgroups.
Data from 715 PACD and 1446 normal subjects were analyzed. Only 6.6% of the PACD eyes had long AL, with lower spherical equivalent, larger anterior chamber depth (P < 0.001), and smaller lens thickness (P < 0.001) than those with short and medium AL. No significant differences were found for angle opening distance and iris parameters on comparing the values of eyes with long AL with that of those with short and medium AL. Significant risk factors for the development of PACD with long AL were peripheral iris thickness, anterior chamber width, and lens vault.
PACD with long AL was uncommon. A thicker peripheral iris, larger lens vault, and smaller ACW contributed to angle closure in these patients.
研究与短、中眼轴长度（AL）相比，长眼轴原发性闭角型青光眼（PACD）的眼前节特征，并探讨与不同 AL 水平的房角相关的危险因素。
本观察性横断面研究纳入了完成邯郸眼病研究随访检查且年龄在 35 岁及以上的受试者，并将其分为正常组和 PACD 组。分析右眼的眼部数据。将 AL 分为短（<22.0mm）、中（22.0-24.0mm）和长（>24.0mm）亚组。比较三组 AL 亚组中 PACD 受试者的人口统计学和眼前节参数。采用 logistic 回归分析确定三组亚组中 PACD 的危险因素。
共分析了 715 例 PACD 和 1446 例正常受试者的数据。仅有 6.6%的 PACD 眼具有长 AL，其球镜等效值较低（P<0.001），前房深度较大（P<0.001），晶状体厚度较小（P<0.001）。与短和中 AL 相比，长 AL 眼的房角开口距离和虹膜参数值无显著差异。长 AL 型 PACD 的显著危险因素为周边虹膜厚度、前房宽度和晶状体拱高。
长 AL 的 PACD 并不常见。较厚的周边虹膜、较大的晶状体拱高和较小的前房宽度有助于这些患者发生房角关闭。
