Gastroenterology Department, University Hospital of Guadalajara, 19002 Guadalajara, Spain.
World J Gastroenterol. 2013 Mar 7;19(9):1354-8. doi: 10.3748/wjg.v19.i9.1354.
The patient with inflammatory bowel disease will be predisposed to numerous infections due their immune status. It is therefore important to understand the immune and serologic status at diagnosis and to put the patient into an adapted vaccination program. This program would be applied differently according to two patient groups: the immunocompromised and the non-immunocompromised. In general, the first group would avoid the use of live-virus vaccines, and in all cases, inflammatory bowel disease treatment would take precedence over vaccine risk. It is important to individualize vaccination schedules according to the type of patient, the treatment used and the disease pattern.In addition, patient with inflammatory bowel disease should be considered for the following vaccines: varicella vaccine, human papilloma virus, influenza, pneumococcal polysaccharide vaccine and hepatitis B vaccine.
由于免疫状态，炎症性肠病患者易发生多种感染。因此，了解诊断时的免疫和血清学状态，并为患者制定适应性疫苗接种计划非常重要。根据免疫抑制和非免疫抑制两组患者，该计划的应用会有所不同。一般来说，第一组会避免使用活病毒疫苗，并且在任何情况下，炎症性肠病的治疗都应优先于疫苗风险。根据患者类型、所用治疗方法和疾病模式，为患者制定个体化的疫苗接种计划非常重要。此外，还应考虑为炎症性肠病患者接种以下疫苗：水痘疫苗、人乳头瘤病毒疫苗、流感疫苗、肺炎球菌多糖疫苗和乙型肝炎疫苗。
