Section of Nephrology, Department of Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
Kidney Int. 2013 Apr;83(4):553-6. doi: 10.1038/ki.2012.462.
Proton pump inhibitors (PPIs) promote hypomagnesemia through loss of active Mg(2+) absorption via transient receptor potential melastatin-6 and -7 (TRPM6/7). Danziger et al. confirm the association of PPIs with hypomagnesemia in patients hospitalized at a tertiary medical center. They found that patients taking PPIs, compared with those receiving histamine-2 antagonists or no acid-suppressive medications, had a decline in serum Mg(2+) after adjusting for several clinical and laboratory factors. The effect was seen only in those concomitantly receiving diuretics.
质子泵抑制剂 (PPIs) 通过瞬时受体电位 melastatin-6 和 -7 (TRPM6/7) 促进镁缺乏症，导致活性 Mg(2+) 吸收减少。Danziger 等人在一所三级医疗中心的住院患者中证实了 PPIs 与镁缺乏症的关联。他们发现，与接受组胺-2 拮抗剂或无酸抑制药物治疗的患者相比，在调整了几个临床和实验室因素后，服用 PPIs 的患者血清 Mg(2+) 下降。这种作用仅见于同时接受利尿剂治疗的患者。
