Department of Obstetrics and Gynecology, Hallym University Dongtan Sacred Heart Hospital, Hwasung, Gyeonggido, Korea.
Med Sci Monit. 2013 Mar 29;19:230-5. doi: 10.12659/MSM.883865.
We aimed to identify clinical characteristics of ovarian mature cystic teratoma (MCT) in association with CA19-9 elevation, and to determine if CA19-9 is a useful marker in discrimination of MCT from ovarian cancer (OC).
Medical records of 322 women with pathologically-confirmed MCT or OC (stage 1 or 2) were reviewed retrospectively. The relationships between the characteristics of MCT (mean diameter, bilaterality, and pathologic components) and elevated CA19-9 were evaluated. Tumor markers in MCT were compared to those in OC.
MCTs with CA19-9 elevation were correlated with a larger diameter (8.53±3.84 cm vs. 6.95±3.97 cm, p=0.002) and presence of fat component (67.1% vs. 32.9%, p<0.001), compared to those with normal CA 19-9. Although the incidence of CA19-9 elevation was not different between patients with MCT and OC (p=0.700), the mean value of CA19-9 was higher in those with OC (114.66±20.66 U/mL vs. 508.58±261.63 U/mL, p=0.013). In addition, simultaneous elevation of CA125 and CA19-9 was associated with a higher probability of malignant neoplasm (p<0.001; odds ratio: 23.7; 95% confidence interval: 8.863-63.576) than single elevation of CA 19-9.
CA19-9 could be an important tool in the diagnosis of ovarian mature cystic teratoma. CA19-9, in combination with CA125, might be a useful marker in discrimination of MCT from cancer.
本研究旨在明确与 CA19-9 升高相关的卵巢成熟囊性畸胎瘤（MCT）的临床特征，并确定 CA19-9 是否有助于区分 MCT 和卵巢癌（OC）。
回顾性分析了 322 例经病理证实为 MCT 或 OC（Ⅰ期或Ⅱ期）患者的病历资料。评估了 MCT 的特征（平均直径、双侧性和病理成分）与 CA19-9 升高之间的关系。比较了 MCT 中的肿瘤标志物与 OC 中的肿瘤标志物。
与 CA19-9 正常的 MCT 相比，CA19-9 升高的 MCT 直径更大（8.53±3.84cm 比 6.95±3.97cm，p=0.002），且含有脂肪成分的比例更高（67.1%比 32.9%，p<0.001）。尽管 MCT 患者与 OC 患者的 CA19-9 升高发生率无差异（p=0.700），但 OC 患者的 CA19-9 平均值更高（114.66±20.66U/mL 比 508.58±261.63U/mL，p=0.013）。此外，CA125 和 CA19-9 同时升高与恶性肿瘤的可能性更高相关（p<0.001；优势比：23.7；95%置信区间：8.863-63.576），而非仅 CA19-9 升高。
CA19-9 可能是诊断卵巢成熟囊性畸胎瘤的重要工具。CA19-9 与 CA125 联合使用可能有助于区分 MCT 和癌症。
