Blessing R E, Schlenter W W
Hals-Nasen-Ohren-Klinik, Medizinischen Universität zu Lübeck.
Laryngorhinootologie. 1990 May;69(5):285-8. doi: 10.1055/s-2007-998191.
A solution of 10% cocaine hydrochloride plus 10% water in 80% dimethyl sulfoxide (DMSO) or 5% tetracaine base in pure DMSO was topically applied to the eardrum in 112 and 52 cases respectively. Both preparations induced well-tolerated analgesia suitable for myringotomy with or without insertion of a grommet in the office environment. DMSO-tetracaine induced analgesia within ten, DMSO-cocaine within 30 minutes. This method has distinct advantages as compared to iontophoretically induced analgesia or topical agents with a destructive mode of action.
分别将含10%盐酸可卡因加10%水的80%二甲基亚砜（DMSO）溶液或纯DMSO中5%丁卡因碱溶液局部应用于112例和52例患者的鼓膜。两种制剂均能诱导出耐受性良好的镇痛效果，适用于在门诊环境下进行鼓膜切开术，无论是否插入通气管。DMSO - 丁卡因在10分钟内诱导出镇痛效果，DMSO - 可卡因在30分钟内诱导出镇痛效果。与离子导入诱导的镇痛或具有破坏作用方式的局部用药相比，该方法具有明显优势。
