Department of Gastroenterology and Hepatology, Digestive Disease Institute, Cleveland Clinic, 9500 Euclid Avenue, A31, Cleveland, OH 44195, USA.
Clin Liver Dis. 2013 May;17(2):211-27. doi: 10.1016/j.cld.2012.11.003. Epub 2012 Dec 20.
Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by multifocal strictures of intra and extrahepatic bile ducts. PSC occurs more commonly in men and is often associated with inflammatory bowel disease. At present, there is no effective medical therapy for PSC. Current management of patients with PSC is centered on endoscopic therapy of biliary strictures, management of complications of chronic cholestasis and of progressive liver disease, and close clinical monitoring for development of cholangiocarcinoma, as well as for timely referral for liver transplantation.
原发性硬化性胆管炎（PSC）是一种慢性、进行性、胆汁淤积性肝病，其特征为肝内外胆管多灶性狭窄。PSC 更常见于男性，常与炎症性肠病相关。目前，PSC 尚无有效的医学治疗方法。目前，PSC 患者的治疗管理主要集中在内镜下胆道狭窄的治疗、慢性胆汁淤积和进行性肝病并发症的管理，以及密切监测胆管癌的发生情况，以及及时转介进行肝移植。
