Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, USA.
Clin Liver Dis. 2013 May;17(2):301-17. doi: 10.1016/j.cld.2012.11.001. Epub 2013 Jan 26.
Systemic causes of cholestasis constitute a diverse group of diseases across organ systems. The pathophysiology of cholestasis in systemic disease can be a consequence of direct involvement of a disease process within the liver or extrahepatic biliary system or secondary to immune-mediated changes in bile flow. Evaluating a patient with cholestasis for a systemic cause requires an understanding of the patient's risk factors, clinical setting (eg, hospitalized or immunosuppressed patient), clinical features, and pattern of laboratory abnormalities.
胆汁淤积的系统性病因涉及多个器官系统的多种疾病。系统性疾病导致的胆汁淤积的病理生理学可能是由于肝脏或肝外胆道系统内疾病过程的直接累及，也可能继发于胆汁流动的免疫介导改变。评估患有胆汁淤积的患者是否存在系统性病因需要了解患者的危险因素、临床背景（例如，住院或免疫抑制患者）、临床特征以及实验室异常模式。
