从癌症基因组中得到的启示。

Lessons from the cancer genome.

机构信息

Department of Medical Oncology and Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

出版信息

Cell. 2013 Mar 28;153(1):17-37. doi: 10.1016/j.cell.2013.03.002.

DOI:10.1016/j.cell.2013.03.002

PMID:23540688

Abstract

Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and lineage maturation. Still, cancer genomics is in its infancy. Much work remains to complete the mutational catalog in primary tumors and across the natural history of cancer, to connect recurrent genomic alterations to altered pathways and acquired cellular vulnerabilities, and to use this information to guide the development and application of therapies.

摘要

近年来，对癌症基因组的系统研究呈爆炸式增长。这些研究揭示了数十个新的癌症基因，其中许多基因涉及以前未知的癌症因果靶点的过程。这些基因影响细胞信号转导、染色质和表观基因组调控、RNA 剪接、蛋白质动态平衡、代谢和谱系成熟。不过，癌症基因组学仍处于起步阶段。要完成原发肿瘤和癌症自然史中的突变目录，将反复出现的基因组改变与改变的途径和获得的细胞脆弱性联系起来，并利用这些信息来指导治疗的开发和应用，还有很多工作要做。