2-羟戊二酸作为脑胶质瘤分型的磁共振生物标志物。
2-hydroxyglutarate as a magnetic resonance biomarker for glioma subtyping.
机构信息
Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway.
出版信息
Transl Oncol. 2013 Apr;6(2):92-8. doi: 10.1593/tlo.12424. Epub 2013 Apr 1.
Abstract
Mutations in the isocitrate dehydrogenase (IDH) genes are frequently found in gliomas and in a fraction of acute myeloid leukemia patients. This results in the production of an oncometabolite, 2-hydroxyglutarate (2-HG). Glioma patients harboring IDH mutations have a longer survival than their wild-type counterparts. 2-HG has been detected noninvasively in gliomas with IDH mutations using magnetic resonance spectroscopy (MRS), suggesting its potential clinical relevance for identifying glioma subtypes with better prognosis. In this paper, the recent developments in the MRS detection of the 2-HG in gliomas are reviewed, including the therapeutic potentials and translational values.
摘要
IDH 基因突变在神经胶质瘤和部分急性髓系白血病患者中经常发现。这导致了一种致癌代谢物 2-羟戊二酸（2-HG）的产生。携带 IDH 突变的神经胶质瘤患者比野生型患者的生存期更长。使用磁共振波谱（MRS）可以非侵入性地检测到 IDH 突变的神经胶质瘤中的 2-HG，这表明它在鉴定预后更好的神经胶质瘤亚型方面具有潜在的临床意义。本文综述了 MRS 检测神经胶质瘤中 2-HG 的最新进展，包括治疗潜力和转化价值。
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