磁共振波谱法检测2-羟基戊二酸作为胶质瘤中异柠檬酸脱氢酶（IDH）突变生物标志物的研究

Magnetic Resonance Spectroscopy for Detection of 2-Hydroxyglutarate as a Biomarker for IDH Mutation in Gliomas.

作者信息

Leather Thomas, Jenkinson Michael D, Das Kumar, Poptani Harish

机构信息

Centre for Pre-clinical Imaging, Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool L69 3BX, UK.

Institute of Translational Medicine, University of Liverpool, Clinical Science Centre, Lower Lane, Liverpool L9 7LJ, UK.

出版信息

Metabolites. 2017 Jun 19;7(2):29. doi: 10.3390/metabo7020029.

Mutations in the isocitrate dehydrogenase (IDH)1/2 genes are highly prevalent in gliomas and have been suggested to play an important role in the development and progression of the disease. Tumours harbouring these mutations exhibit a significant alteration in their metabolism resulting in the aberrant accumulation of the oncometabolite 2-hydroxygluarate (2-HG). As well as being suggested to play an important role in tumour progression, 2-HG may serve as a surrogate indicator of IDH status through non-invasive detection using magnetic resonance spectroscopy (MRS). In this review, we describe the recent efforts in developing MRS methods for detection and quantification of 2-HG in vivo and provide an assessment of the role of the 2-HG in gliomagenesis and patient prognosis.