Leather Thomas, Jenkinson Michael D, Das Kumar, Poptani Harish
Centre for Pre-clinical Imaging, Department of Cellular and Molecular Physiology, University of Liverpool, Liverpool L69 3BX, UK.
Institute of Translational Medicine, University of Liverpool, Clinical Science Centre, Lower Lane, Liverpool L9 7LJ, UK.
Metabolites. 2017 Jun 19;7(2):29. doi: 10.3390/metabo7020029.
Mutations in the isocitrate dehydrogenase (IDH)1/2 genes are highly prevalent in gliomas and have been suggested to play an important role in the development and progression of the disease. Tumours harbouring these mutations exhibit a significant alteration in their metabolism resulting in the aberrant accumulation of the oncometabolite 2-hydroxygluarate (2-HG). As well as being suggested to play an important role in tumour progression, 2-HG may serve as a surrogate indicator of IDH status through non-invasive detection using magnetic resonance spectroscopy (MRS). In this review, we describe the recent efforts in developing MRS methods for detection and quantification of 2-HG in vivo and provide an assessment of the role of the 2-HG in gliomagenesis and patient prognosis.
异柠檬酸脱氢酶（IDH）1/2基因的突变在胶质瘤中非常普遍，并且被认为在该疾病的发生和发展中起重要作用。携带这些突变的肿瘤在代谢上表现出显著改变，导致肿瘤代谢物2-羟基戊二酸（2-HG）异常积累。2-HG除了被认为在肿瘤进展中起重要作用外，还可以通过磁共振波谱（MRS）进行非侵入性检测，作为IDH状态的替代指标。在这篇综述中，我们描述了最近在开发用于体内检测和定量2-HG的MRS方法方面所做的努力，并评估了2-HG在胶质瘤发生和患者预后中的作用。
