Schischmanov Nicola
Nagoya J Med Sci. 2013 Feb;75(1-2):153-9.
A new hypothesis for the origin of metastases is presented. It assumes that a cancer-transformed gene in a primary tumour is incorporated in its identical form via a virus-vector function into biologically potent recipient cells in other organs, such as stem cells, multipotent cells or cells in an early phase of division. The origin of metastases may thus possibly occur via a genetic pathway.
提出了一种关于转移瘤起源的新假说。该假说认为,原发性肿瘤中一个发生癌转化的基因通过病毒载体功能以其相同形式整合到其他器官中具有生物学活性的受体细胞中,如干细胞、多能细胞或处于分裂早期的细胞。因此,转移瘤的起源可能通过遗传途径发生。