Université Libre de Bruxelles, IRIBHM and WELBIO, Brussels, Belgium.
Nat Cell Biol. 2013 Feb;15(2):126-34. doi: 10.1038/ncb2657. Epub 2013 Jan 20.
Although many genes that lead to different types of cancer when mutated have been identified, the cells that initiate tumour formation following accumulation of these mutations have, until recently, remained elusive. This review explores how mouse genetic lineage-tracing experiments that allow the expression of oncogenes and/or the deletion of tumour suppressor genes in defined cell lineages have been instrumental in defining the cellular origin of different solid tumours in mouse models for various human cancers.
虽然已经鉴定出许多导致不同类型癌症的基因突变，但直到最近，在这些突变积累后引发肿瘤形成的细胞仍然难以捉摸。本综述探讨了如何利用允许在特定细胞谱系中表达癌基因和/或删除肿瘤抑制基因的小鼠遗传谱系追踪实验，有助于确定不同人类癌症的小鼠模型中不同实体瘤的细胞起源。
