College of Chemistry and Materials Engineering, Wenzhou University, Zhejiang 325035, China.
Mini Rev Med Chem. 2013 May 1;13(6):824-35. doi: 10.2174/1389557511313060005.
Organophosphorus compounds are of high importance in organic synthesis, catalysis, biochemistry, pharmaceuticals, and material science. In this mini review, we summarize our recent studies on transition metal-catalyzed green and atom efficient transformations of P(O)-H bonds to various versatile organophosphorus compounds, including the highly regio- and stereoselective P(O)-H additions to carbon-carbon unsaturated compounds, asymmetric hydrophosphorylation reactions, and dehydrogenative coupling reactions of P(O)-H compounds with carbon-H and heteroatom-H compounds. These new reactions provide efficient, general and practical ways for the preparation of a variety of well-defined functional organophosphorus compounds. Mechanistic aspects related to the catalytic processes are also discussed.
有机磷化合物在有机合成、催化、生物化学、制药和材料科学等领域具有重要意义。在这篇综述中，我们总结了我们最近关于过渡金属催化的绿色、高效原子转化 P(O)-H 键到各种多功能有机磷化合物的研究，包括对碳-碳不饱和化合物的高区域和立体选择性 P(O)-H 加成、不对称氢膦化反应以及 P(O)-H 化合物与碳-H 和杂原子-H 化合物的脱氢偶联反应。这些新反应为制备各种定义明确的功能有机磷化合物提供了有效、通用和实用的方法。还讨论了与催化过程相关的机理方面。
