Department of Chemistry, Wuhan University, Wuhan 430072, China.
Carbohydr Polym. 2013 Apr 15;94(1):386-93. doi: 10.1016/j.carbpol.2012.12.077. Epub 2013 Jan 23.
β-Cyclodextrin (β-CD)/cellulose hydrogels were prepared in NaOH/urea aqueous solution by crosslinking with epichlorohydrin. The structure and morphology of the hydrogels were characterized with Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM). The swelling test, 5-fluorouracil (5-FU) and bovine serum albumin (BSA), and aniline blue (AnB) were used to investigate the swelling capability, drug release behavior and the fluorescent property of the hydrogels. The results indicated that the swelling degree and water uptake of the hydrogels decreased with an increase of the β-CD content. The in vitro release of 5-FU and BSA of the hydrogels showed an inclusion complex formed between 5-FU and β-CD. β-CD/cellulose hydrogels adsorbed AnB lead to a fluorescence enhancement attributing to the formation of the host-guest complex between β-CD and AnB.
β-环糊精（β-CD）/纤维素水凝胶是通过与表氯醇交联在 NaOH/尿素水溶液中制备的。用傅里叶变换红外光谱（FTIR）、X 射线衍射（XRD）、扫描电子显微镜（SEM）对水凝胶的结构和形态进行了表征。通过溶胀试验、5-氟尿嘧啶（5-FU）和牛血清白蛋白（BSA）以及吖啶蓝（AnB）研究了水凝胶的溶胀性能、药物释放行为和荧光性能。结果表明，水凝胶的溶胀度和吸水率随β-CD 含量的增加而降低。水凝胶对 5-FU 和 BSA 的体外释放显示 5-FU 与β-CD 之间形成了包合物。β-CD/纤维素水凝胶吸附 AnB 导致荧光增强，归因于β-CD 和 AnB 之间形成主客体配合物。
