Department of Medical Chemistry, Medical University of Warsaw, Oczki 3 Street, 02-007 Warsaw, Poland.
Mini Rev Med Chem. 2013 Jun;13(7):933-51. doi: 10.2174/1389557511313070001.
The present paper discusses models of 5-HT(1A) and 5-HT(2A) receptors, developed by conformational analysis and 3D-QSAR methods. Hypotheses concerning the ligand-5-HT(7) receptor interaction were complemented by models constructed on the basis of the receptor's structure. Various pharmacophore concepts are supported by structures of exemplary ligands and groups of compounds, derived from chain polycyclic arylpiperazines, used for models generations.
本文讨论了通过构象分析和 3D-QSAR 方法开发的 5-HT(1A)和 5-HT(2A)受体模型。关于配体-5-HT(7)受体相互作用的假设通过基于受体结构构建的模型得到了补充。各种药效基团概念得到了示例配体和链多环芳基哌嗪衍生的化合物组结构的支持，这些结构用于模型生成。
