Department of Food and Nutrition, School of Food Engineering, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil.
J Pediatr (Rio J). 2013 Jan-Feb;89(1):40-7. doi: 10.1016/j.jped.2013.02.007.
To compare the immunologic state of 44 pediatric patients with cystic fibrosis (CF) with a control group consisting of 16 healthy individuals.
CF patients aged 3 to 12 years with moderate to good clinical score were selected for the study. Erythrocytic glutathione, production of reactive oxygen species, cytokines (TNF-a, IFN-g, IL-8, IL-6, IL-10) in peripheral blood mononuclear cells cultures under spontaneous and BCG- or PHA-stimulated conditions, serum concentrations of TGF-b2, IgA, IgG, IgM, IgE, and salivary IgA were evaluated.
The spontaneous production of TNF-a, IL-6, and IL-10, the PHA-stimulated production of IL-6, and the serum TGF-b2, IgA, and IgG were increased in samples from CF patients. Healthy subjects had a higher production of TNF-a in response to BCG.
Although CF patients appeared clinically stable, the results of their peripheral blood examinations demonstrated an impact on the immune system.
比较 44 例囊性纤维化（CF）儿科患者与由 16 名健康个体组成的对照组的免疫状态。
选择年龄在 3 至 12 岁、临床评分中等到良好的 CF 患者进行研究。评估外周血单个核细胞培养中红细胞谷胱甘肽、活性氧产生、细胞因子（TNF-a、IFN-g、IL-8、IL-6、IL-10）在自发和 BCG 或 PHA 刺激条件下的产生情况、血清 TGF-b2、IgA、IgG、IgM、IgE 和唾液 IgA 的浓度。
CF 患者的 TNF-a、IL-6 和 IL-10 的自发产生、PHA 刺激的 IL-6 产生以及血清 TGF-b2、IgA 和 IgG 增加。健康受试者对 BCG 的 TNF-a 产生更高。
尽管 CF 患者在临床上似乎稳定，但他们外周血检查的结果表明对免疫系统有影响。
