Department of Molecular Genetics, The Ohio State University, Columbus, OH 43210, United States.
Mol Cell Endocrinol. 2013 Nov 5;380(1-2):25-31. doi: 10.1016/j.mce.2013.03.020. Epub 2013 Mar 29.
The glucocorticoid receptor (GR) functions to regulate a wide group of physiological processes through hormone inducible interaction with genomic loci and subsequent manipulation of the transcriptional output of target genes. Despite expression in a wide variety of tissues, the GR has diverse roles that are regulated tightly in a cell type specific manner. With the advent of whole genome approaches, the details of that diversity and the mechanisms regulating them are beginning to be elucidated. This review aims describe the recent advances detailing the role chromatin structure plays in dictating GR specificity.
糖皮质激素受体 (GR) 通过与基因组位置的激素诱导相互作用，并随后操纵靶基因的转录输出，从而调节广泛的生理过程。尽管在多种组织中表达，但 GR 具有多种作用，这些作用以细胞类型特异性的方式受到严格调节。随着全基因组方法的出现，这种多样性的细节及其调节机制开始被阐明。本文旨在描述最近的进展，详细说明染色质结构在决定 GR 特异性方面的作用。
