Dietrich Nicholas, Hoffman Jackson A, Archer Trevor K
Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, North Carolina, United States.
Curr Opin Endocr Metab Res. 2020 Dec;15:8-14. doi: 10.1016/j.coemr.2020.07.001. Epub 2020 Sep 6.
Breast cancers are a diverse group of diseases and are often characterized by their expression of receptors for hormones such as estrogen and progesterone. Recently another steroid hormone receptor, the glucocorticoid receptor (GR) has been shown to be a key player in breast cancer progression, metastasis, and treatment. These receptors bind to chromatin to elicit transcriptional changes within cells, which are often inhibited by the structure of chromatin itself. Chromatin remodeling proteins, such as Brahma-related gene 1 (BRG1), function to overcome this physical inhibition of transcription factor function and have been linked to many cancers including breast cancer. Recent efforts to understand the interactions of BRG1 and GR, including genomic and single cell analyses, within breast cancers may give insight into personalized medicine and other potential treatments.
乳腺癌是一组多样的疾病，通常以其对雌激素和孕激素等激素受体的表达为特征。最近，另一种类固醇激素受体，即糖皮质激素受体（GR），已被证明是乳腺癌进展、转移和治疗中的关键因素。这些受体与染色质结合，引发细胞内的转录变化，而这种变化常常受到染色质自身结构的抑制。染色质重塑蛋白，如与布拉马相关基因1（BRG1），其功能是克服转录因子功能的这种物理抑制，并且与包括乳腺癌在内的许多癌症有关。最近在乳腺癌中了解BRG1和GR相互作用的研究工作，包括基因组分析和单细胞分析，可能会为个性化医疗和其他潜在治疗方法提供见解。
